Evidence map›Paper›PMID 18606839›Full record

Trial reportAntimicrobial agents and chemotherapy2008

Microbiological and genotypic analysis of methicillin-resistant Staphylococcus aureus bacteremia.

Carlo McCalla, Davida S Smyth, D Ashley Robinson, Judith Steenbergen, Steven A Luperchio, Pamela A Moise, Vance G Fowler, George Sakoulas

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlo McCallaDepartment of Medicine, New York Medical College, Valhalla, New York 10595, USA. george_sakoulas@nymc.edu
Davida S Smyth
D Ashley Robinson
Judith Steenbergen
Steven A Luperchio
Pamela A Moise
Vance G Fowler
George Sakoulas

Funding

Population Genomics of StaphylococciR01GM080602 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROBINSON, DAVID ASHLEY · 2007 to 2016
$1.8M
NIGMS NIH HHS GM080602NIGMS NIH HHS R01 GM080602
6 · The paper itself

Abstract

In a recent landmark trial of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) isolates, vancomycin MICs were >or=1 microg/ml for only 16% of the isolates, and accessory gene regulator (agr) function as measured by delta-hemolysin activity was absent or reduced in only 28.1% of the isolates. This clinical study did not capture a population of MRSA isolates predictive of vancomycin treatment failure.

Indexed as

Methicillin ResistanceAnti-Bacterial AgentsBacteremiaBacterial ProteinsDaptomycinEndocarditis, BacterialGenotypeHemolysin ProteinsHumansStaphylococcal InfectionsStaphylococcus aureusTreatment OutcomeVancomycinAnti-Bacterial AgentsBacterial ProteinsDaptomycindelta hemolysin protein, Staphylococcus aureusHemolysin ProteinsVancomycin

Identifiers

PMID18606839
PMCPMC2533503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.