ArticleAntimicrobial agents and chemotherapy2008
Efficient clearance of Aspergillus fumigatus in murine lungs by an ultrashort antimicrobial lipopeptide, palmitoyl-lys-ala-DAla-lys.
Article in Antimicrobial agents and chemotherapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Synthesis and Biological Activity of Ultrashort Antimicrobial Peptides Bearing a Non-Coded Amino Acid.Journal of peptide science : an official publication of the European Peptide Society · 2025Article
- Use of red, far-red, and near-infrared light in imaging of yeasts and filamentous fungi.Applied microbiology and biotechnology · 2022Review
- Article
- Interaction of Antimicrobial Lipopeptides with Bacterial Lipid Bilayers.The Journal of membrane biology · 2019Article
- Antibacterial Activities of Lipopeptide (CInternational journal of molecular sciences · 2019Article
- Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential.Chemical communications (Cambridge, England) · 2017Article
- Synthetic Cyclolipopeptides Selective against Microbial, Plant and Animal Cell Targets by Incorporation of D-Amino Acids or Histidine.PloS one · 2016Article
- Thermodynamics of Micelle Formation and Membrane Fusion Modulate Antimicrobial Lipopeptide Activity.Biophysical journal · 2015Article
- Thermodynamics of antimicrobial lipopeptide binding to membranes: origins of affinity and selectivity.Biophysical journal · 2014Article
- Antifungal amphiphilic aminoglycoside K20: bioactivities and mechanism of action.Frontiers in microbiology · 2014Article
- Article
- Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B.Antimicrobial agents and chemotherapy · 2012Article
- Beyond natural antimicrobial peptides: multimeric peptides and other peptidomimetic approaches.Cellular and molecular life sciences : CMLS · 2011Review
- The potential of antimicrobial peptides as biocides.International journal of molecular sciences · 2011Review
- Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold.Antimicrobial agents and chemotherapy · 2010Review
- Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin.Antimicrobial agents and chemotherapy · 2010Article
- Synthetic ultrashort cationic lipopeptides induce systemic plant defense responses against bacterial and fungal pathogens.Applied and environmental microbiology · 2009Article
- De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- De novo designed synthetic mimics of antimicrobial peptides.Current opinion in biotechnology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspergillus fumigatus is an opportunistic fungal pathogen responsible for invasive aspergillosis in immunocompromised individuals. The inefficiency of antifungal agents and high mortality rate resulting from invasive aspergillosis remain major clinical concerns. Recently, we reported on a new family of ultrashort cationic lipopeptides active in vitro against fungi. Mode of action studies supported a membranolytic or a detergent-like effect. Here, we screened several lipopeptides in vitro for their anti-A. fumigatus activity. To investigate the therapeutic properties of the selected peptides in vivo, we challenged immunosuppressed C57BL/6 wild-type mice intranasally with DsRed-labeled A. fumigatus conidia and subsequently treated the animals locally with the lipopeptides. Confocal microscopic analysis revealed the degradation of DsRed-labeled hyphal forms and residual conidia in the lungs of the mice. The most efficient peptide was tested further using a survival assay and was found to significantly prolong the life of the treated animals, whereas no mice survived with the current standard antifungal treatment with amphotericin B. Moreover, as opposed to the drug-treated lungs, the peptide-treated lungs did not display any toxicity of the peptide. Our results highlight the potential of this family of lipopeptides for the treatment of pulmonary invasive aspergillosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.