ArticleThe Journal of biological chemistry2008
Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Adaptations in rod outer segment disc membranes in response to environmental lighting conditions.Biochimica et biophysica acta. Molecular cell research · 2017Article
- Enhanced atheroprotection and lesion remodelling by targeting the foam cell and increasing plasma cholesterol acceptors.Cardiovascular research · 2016Article
- Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration.Human molecular genetics · 2015Article
- Third harmonic generation microscopy of a mouse retina.Molecular vision · 2015Article
- Chemistry and biology of the initial steps in vision: the Friedenwald lecture.Investigative ophthalmology & visual science · 2014Article
- Submembrane assembly and renewal of rod photoreceptor cGMP-gated channel: insight into the actin-dependent process of outer segment morphogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.Autophagy · 2014Article
- Chemistry of the retinoid (visual) cycle.Chemical reviews · 2014Review
- Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice.PloS one · 2014Article
- Delayed liver regeneration after partial hepatectomy in adipose differentiation related protein-null mice.Journal of hepatology · 2013Article
- Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.The Journal of biological chemistry · 2013Article
- Coherent anti-stokes Raman scattering (CARS) microscopy: a novel technique for imaging the retina.Investigative ophthalmology & visual science · 2013Article
- Article
- Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues.The Journal of biological chemistry · 2011Article
- Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations.The Journal of biological chemistry · 2011Article
- Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes.Nature medicine · 2010Article
- Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice.Journal of lipid research · 2010Article
- Retinoids for treatment of retinal diseases.Trends in pharmacological sciences · 2010Review
- Visualization of retinoid storage and trafficking by two-photon microscopy.Methods in molecular biology (Clifton, N.J.) · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The retinal pigmented epithelium (RPE) plays an essential role in vision, including storing and converting retinyl esters of the visual chromophore, 11-cis-retinal. Retinyl ester storage structures (RESTs), specialized lipid droplets within the RPE, take up retinyl esters synthesized in the endoplasmic reticulum. Here we report studies of mice lacking exons 2 and 3 of the gene encoding adipose differentiation-related protein (Adfp), a structural component of RESTs. We found that dark adaptation was slower in Adfp(Delta2-3/Delta2-3) than in Adfp+/+ mice and that Adfp(Delta2-3/Delta2-3) mice had consistently delayed clearances of all-trans-retinal and all-trans-retinol from rod photoreceptor cells. Two-photon microscopy revealed aberrant trafficking of all-trans-retinyl esters in the RPE of Adfp(Delta2-3/Delta2-3) mice, a problem caused by abnormal maintenance of RESTs in the dark-adapted state. Retinyl ester accumulation was also reduced in Adfp(Delta2-3/Delta2-3) as compared with Adfp+/+ mice. These observations suggest that Adfp plays a unique role in vision by maintaining proper storage and trafficking of retinoids within the eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.