ArticleJournal of bacteriology2008
Lawsonia intracellularis contains a gene encoding a functional rickettsia-like ATP/ADP translocase for host exploitation.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Infection of juvenile falcons (Falco spp.) with intestinal Lawsonia intracellularis.Veterinary medicine and science · 2023Article
- Engineering artificial photosynthetic life-forms through endosymbiosis.Nature communications · 2022Article
- Transcriptome Analysis Identifies Plasmodiophora brassicae Secondary Infection Effector Candidates.The Journal of eukaryotic microbiology · 2020Article
- Review
- Phylogenetic Diversity of NTT Nucleotide Transport Proteins in Free-Living and Parasitic Bacteria and Eukaryotes.Genome biology and evolution · 2017Article
- Developmental Cycle and Genome Analysis of "Rubidus massiliensis," a New Vermamoeba vermiformis Pathogen.Frontiers in cellular and infection microbiology · 2016Article
- Single-cell genomics of a rare environmental alphaproteobacterium provides unique insights into Rickettsiaceae evolution.The ISME journal · 2015Article
- Minimization of extracellular space as a driving force in prokaryote association and the origin of eukaryotes.Biology direct · 2014Article
- Chlamydia trachomatis transports NAD via the Npt1 ATP/ADP translocase.Journal of bacteriology · 2013Article
- Laser microdissection coupled with RNA-seq analysis of porcine enterocytes infected with an obligate intracellular pathogen (Lawsonia intracellularis).BMC genomics · 2013Article
- Article
- Nucleotide parasitism by Simkania negevensis (Chlamydiae).Journal of bacteriology · 2011Article
- Characterization of an ATP translocase identified in the destructive plant pathogen "Candidatus Liberibacter asiaticus".Journal of bacteriology · 2010Article
- The genome of the amoeba symbiont "Candidatus Amoebophilus asiaticus" reveals common mechanisms for host cell interaction among amoeba-associated bacteria.Journal of bacteriology · 2010Article
- Diatom plastids depend on nucleotide import from the cytosol.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Nonmitochondrial ATP/ADP transporters accept phosphate as third substrate.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
ATP/ADP translocases are a hallmark of obligate intracellular pathogens related to chlamydiae and rickettsiae. These proteins catalyze the highly specific exchange of bacterial ADP against host ATP and thus allow bacteria to exploit their hosts' energy pool, a process also referred to as energy parasitism. The genome sequence of the obligate intracellular pathogen Lawsonia intracellularis (Deltaproteobacteria), responsible for one of the most economically important diseases in the swine industry worldwide, revealed the presence of a putative ATP/ADP translocase most similar to known ATP/ADP translocases of chlamydiae and rickettsiae (around 47% amino acid sequence identity). The gene coding for the putative ATP/ADP translocase of L. intracellularis (L. intracellularis nucleotide transporter 1 [NTT1(Li)]) was cloned and expressed in the heterologous host Escherichia coli. The transport properties of NTT1(Li) were determined by measuring the uptake of radioactively labeled substrates by E. coli. NTT1(Li) transported ATP in a counterexchange mode with ADP in a highly specific manner; the substrate affinities determined were 236.3 (+/- 36.5) microM for ATP and 275.2 (+/- 28.1) microM for ADP, identifying this protein as a functional ATP/ADP translocase. NTT1(Li) is the first ATP/ADP translocase from a bacterium not related to Chlamydiae or Rickettsiales, showing that energy parasitism by ATP/ADP translocases is more widespread than previously recognized. The occurrence of an ATP/ADP translocase in L. intracellularis is explained by a relatively recent horizontal gene transfer event with rickettsiae as donors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.