ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- A comparative mathematical modeling study of phenotypic approaches to T cell activation.Scientific reports · 2025Article
- The Multifaceted Role of the IL-2 Cytokine Family in Melanoma: Mechanisms, Therapeutic Implications, and Immune Modulation.Journal of immunology research · 2025Review
- Comprehensive Analysis Identifies PI3K/Akt Pathway Alternations as an Immune-Related Prognostic Biomarker in Colon Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitor Treatment.Journal of immunology research · 2022Article
- TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways.Journal for immunotherapy of cancer · 2019Article
- Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.The Journal of experimental medicine · 2016Article
- TNFR2 Deficiency Acts in Concert with Gut Microbiota To Precipitate Spontaneous Sex-Biased Central Nervous System Demyelinating Autoimmune Disease.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Transmembrane TNF-TNFR2 Impairs Th17 Differentiation by Promoting Il2 Expression.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Activation of silenced cytokine gene promoters by the synergistic effect of TBP-TALE and VP64-TALE activators.PloS one · 2014Article
- Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance.Immunity · 2013Article
- A corticoid-sensitive cytokine release assay for monitoring stress-mediated immune modulation.Clinical and experimental immunology · 2013Article
- The dynamic lives of T cells: new approaches and themes.Trends in immunology · 2013Review
- Cutting edge: Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NF-κB nuclear accumulation in CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Polyfunctional responses by human T cells result from sequential release of cytokines.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Two-step binding of transcription factors causes sequential chromatin structural changes at the activated IL-2 promoter.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Article
- Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression.Immunology · 2010Review
- Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.Nature genetics · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We describe a novel biphasic regulation of Il2 transcription in naive CD4(+) T cells. Few ( approximately 5%) CD4(+) T cells transcribe Il2 within 6 h of anti-TCR-beta plus anti-CD28 stimulation (early phase). Most naive CD4(+) T cells do not initiate Il2 transcription until after an additional approximately 12 h of T cell stimulation (late phase). In comparison, essentially all previously activated (Pre-Ac) CD4(+) T cells that transcribe Il2 do so with an early-phase response. Late-phase Il2 expression mostly requires c-Rel, CD28, and TNFR signaling. In contrast, early-phase transcription is only partly c-Rel and CD28 dependent and TNFR independent. There was also increased stable DNA accessibility at the Il2 locus and elevated c-Rel expression in resting Pre-Ac CD4(+) cells. Upon T cell activation, a faster and greater increase in DNA accessibility as well as c-Rel nuclear expression were observed in Pre-Ac CD4(+) cells relative to naive CD4(+) T cells. In addition, both acetylated histone H3 and total H3 decreased at the Il2 locus upon rechallenge of Pre-Ac CD4(+) T cells, whereas increased acetylated histone H3 with no change in total H3 was observed following activation of naive CD4(+) T cells. We propose a model in which nucleosome disassembly facilitates rapid initiation of Il2 transcription in CD4(+) T cells, and suggest that a threshold level of c-Rel must be reached for Il2 promoter activity in both naive and Pre-Ac CD4(+) T cells. This is provided, at least partially, by TNFR signaling during priming, but not during recall.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.