ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Lambda light chain revision in the human intestinal IgA response.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus.European journal of immunology · 2015Trial
- Human intestinal B cells in inflammatory diseases.Nature reviews. Gastroenterology & hepatology · 2023Review
- Clinicopathologic Significance of Predominant Lambda Light Chain Deposition in IgA Nephropathy.Kidney international reports · 2022Article
- Further Evidence for the Mucosal Origin of Pathogenic IgA in IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2022Article
- Presence of Natural Killer B Cells in Simian Immunodeficiency Virus-Infected Colon That Have Properties and Functions Similar to Those of Natural Killer Cells and B Cells but Are a Distinct Cell Population.Journal of virology · 2022Article
- Gut Mucosal Antibody Responses and Implications for Food Allergy.Frontiers in immunology · 2018Review
- The human intestinal B-cell response.Mucosal immunology · 2016Review
- Circulating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive Igs.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Toll-like receptor 2 as a regulator of oral tolerance in the gastrointestinal tract.Mediators of inflammation · 2014Review
- The intestinal B-cell response in celiac disease.Frontiers in immunology · 2012Article
- The human intestinal IgA response; burning questions.Frontiers in immunology · 2012Article
- Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjögren's syndrome: clinical implications and effects of B cell-targeted therapies.Clinical and experimental immunology · 2012Review
- Article
- IgA-producing plasma cells originate from germinal centers that are induced by B-cell receptor engagement in humans.Gastroenterology · 2011Article
- Gene expression profile of bladder tissue of patients with ulcerative interstitial cystitis.BMC genomics · 2009Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Revision of Ab L chains by secondary rearrangement in mature B cells has the potential to change the specific target of the immune response. In this study, we show for the first time that L chain revision is normal and widespread in the largest Ab producing population in man: intestinal IgA plasma cells (PC). Biases in the productive and non-productive repertoire of lambda L chains, identification of the circular products of rearrangement that have the characteristic biases of revision, and identification of RAG genes and protein all reflect revision during normal intestinal IgA PC development. We saw no evidence of IgH revision, probably due to inappropriately orientated recombination signal sequences, and little evidence of kappa-chain revision, probably due to locus inactivation by the kappa-deleting element. We propose that the lambda L chain locus is available and a principal modifier and diversifier of Ab specificity in intestinal IgA PCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.