ArticleNeurobiology of aging2010
APOE genotype is associated with left-handedness and visuospatial skills in children.
Article in Neurobiology of aging, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans.Neuroscience and biobehavioral reviews · 2018Pooled it
- Pooled it
- Apolipoprotein E4 influences growth and cognitive responses to micronutrient supplementation in shantytown children from northeast Brazil.Clinics (Sao Paulo, Brazil) · 2012Trial
- Shared genetic and molecular architecture between insulin resistance and cognitive performance.medRxiv : the preprint server for health sciences · 2026Article
- Apolipoprotein-E4: risk of severe malaria and mortality and cognitive impairment in pediatric cerebral malaria.Pediatric research · 2024Article
- Understanding the interplay between APO E polymorphism and cognition in the Italian oldest old: results from the "Mugello study".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Asymmetric left-right hippocampal glutamatergic modulation of cognitive control in ApoE-isoform subjects is unrelated to neuroinflammation.The European journal of neuroscience · 2021Article
- When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age.Neuropsychologia · 2019Article
- Review
- Putative Survival Advantages in Young Apolipoprotein ɛ4 Carriers are Associated with Increased Neural Stress.Journal of Alzheimer's disease : JAD · 2019Review
- Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation.Neurobiology of aging · 2019Article
- Non-right handed primary progressive apraxia of speech.Journal of the neurological sciences · 2018Article
- The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses.Frontiers in psychology · 2017Article
- Article
- MAOA Influences the Trajectory of Attentional Development.Frontiers in human neuroscience · 2016Article
- Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study.BMC psychiatry · 2014Article
- The genetic relationship between handedness and neurodevelopmental disorders.Trends in molecular medicine · 2014Review
- Handedness genetics: considering the phenotype.Frontiers in psychology · 2014Article
- Differences in cerebral cortical anatomy of left- and right-handers.Frontiers in psychology · 2014Article
- APOE associated hemispheric asymmetry of entorhinal cortical thickness in aging and Alzheimer's disease.Psychiatry research · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We sought to investigate whether apolipoprotein E (APOE) genotype is associated with unique profiles of cognitive functioning during early-life. School-aged children (N=147) received standardized achievement tests, the Rey-Osterrieth Complex Figure Test (Copy Condition; RCFT-CC), assessment of hand dominance for writing, and buccal swab testing to determine their APOE genotype. Significant differences were found on the RCFT-CC, with epsilon 2-positive children performing worse on this measure relative to both epsilon 3/3 (p=0.032) and epsilon 4-positive children (p=0.018). Further, a higher prevalence of left-hand dominance for writing was observed among epsilon 2-positive children (29.2%) relative to epsilon 3/3 (8.9%) and epsilon 4-positive children (6.1%; p=0.012), although this finding did not account for the observed group differences on the RCFT-CC. Findings raise the possibility that in childhood, the epsilon 2 allele may be associated with: (a) decreased functioning in certain cognitive domains; (b) factors associated with atypical hemispheric dominance. Results may be consistent with the theory of antagonistic pleiotropy, which suggests that APOE may have different protective effects at different developmental stages.
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