ReviewCurrent allergy and asthma reports2008
The spectrum of monogenic autoinflammatory syndromes: understanding disease mechanisms and use of targeted therapies.
Review in Current allergy and asthma reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS).Arthritis research & therapy · 2011Trial
- Behçet-like Syndromes: A Comprehensive Review.Dermatopathology (Basel, Switzerland) · 2026Review
- Cutaneous vasculitis in autoinflammatory diseases.The Journal of dermatology · 2024Review
- Awareness and knowledge of familial Mediterranean fever among medical scope students in Syrian universities: A cross-sectional study.SAGE open medicine · 2023Article
- Autoinflammatory manifestations in adult patients.Clinical and experimental immunology · 2022Article
- Systemic autoinflammatory diseases in pediatric population.Asia Pacific allergy · 2022Article
- Integrating Patient-Specific Information into Logic Models of Complex Diseases: Application to Acute Myeloid Leukemia.Journal of personalized medicine · 2021Article
- [Efficacy and safety analysis of off-label treatment with biologics in autoinflammatory diseases : Experiences from a German registry (GRAID2)].Zeitschrift fur Rheumatologie · 2018Article
- Review
- Anti-interleukin 1 treatment in secondary amyloidosis associated with autoinflammatory diseases.Pediatric nephrology (Berlin, Germany) · 2016Article
- Early detection of sensorineural hearing loss in Muckle-Wells-syndrome.Pediatric rheumatology online journal · 2015Article
- A clinical guide to autoinflammatory diseases: familial Mediterranean fever and next-of-kin.Nature reviews. Rheumatology · 2014Review
- Canakinumab in patients with cryopyrin-associated periodic syndrome: an update for clinicians.Therapeutic advances in musculoskeletal disease · 2013Review
- Monogenic autoinflammatory diseases: concept and clinical manifestations.Clinical immunology (Orlando, Fla.) · 2013Review
- Autoinflammation: From monogenic syndromes to common skin diseases.Journal of the American Academy of Dermatology · 2013Review
- Clinical characteristics in subjects with NLRP3 V198M diagnosed at a single UK center and a review of the literature.Arthritis research & therapy · 2013Article
- [Comments on the pathogenesis of Behçet's disease. A key to understanding new therapies?].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2012Article
- [Cryopyrin-associated periodic syndrome].Zeitschrift fur Rheumatologie · 2012Article
- A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: description of two unrelated cases from Brazil.Arthritis and rheumatism · 2011Article
- The emerging role of interleukin-1β in autoinflammatory diseases.Current allergy and asthma reports · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases present clinically with episodes of seemingly unprovoked inflammation (fever, rashes, and elevation of acute phase reactants). Understanding the genetics has led to discovery of new molecules involved in recognizing exogenous and endogenous danger signals, and the inflammatory response to these stimuli. These advances have furthered understanding of innate inflammatory pathways and spurred collaborative research in rheumatology and infectious diseases. The pivotal roles of interleukin (IL)-1beta in cryopyrin-associated periodic syndromes, tumor necrosis factor (TNF) in TNF receptor-associated periodic syndrome, and links to inflammatory cytokine dysregulation in other monogenic autoinflammatory diseases have resulted in effective therapies targeting proinflammatory cytokines IL-1beta and TNF and uncovered other new potential targets for anti-inflammatory therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.