ArticleBMC genomics2008
T2D-Db: an integrated platform to study the molecular basis of Type 2 diabetes.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- DiabetesOmic: A comprehensive multi-omics diabetes database.Computational and structural biotechnology journal · 2025Article
- Prioritization of genes associated with type 2 diabetes mellitus for functional studies.Nature reviews. Endocrinology · 2023Review
- On building a diabetes centric knowledge base via mining the web.BMC medical informatics and decision making · 2019Article
- A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals.BMC genomics · 2018Article
- T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders.Scientific reports · 2017Article
- Genetic variants inExperimental and therapeutic medicine · 2017Article
- OCDD: an obesity and co-morbid disease database.BioData mining · 2017Article
- Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review.Frontiers in pharmacology · 2017Review
- Article
- Identifying module biomarker in type 2 diabetes mellitus by discriminative area of functional activity.BMC bioinformatics · 2015Article
- Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.Pharmacology & therapeutics · 2013Review
- metabolicMine: an integrated genomics, genetics and proteomics data warehouse for common metabolic disease research.Database : the journal of biological databases and curation · 2013Article
- T2D@ZJU: a knowledgebase integrating heterogeneous connections associated with type 2 diabetes mellitus.Database : the journal of biological databases and curation · 2013Article
- T-HOD: a literature-based candidate gene database for hypertension, obesity and diabetes.Database : the journal of biological databases and curation · 2013Article
- Type 2 diabetes genetic association database manually curated for the study design and odds ratio.BMC medical informatics and decision making · 2010Article
- Analyses of copy number variation of GK rat reveal new putative type 2 diabetes susceptibility loci.PloS one · 2010Article
- Decisions to seek healthcare based on family health history among urban Appalachian women.Journal of genetic counseling · 2009Article
- Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers.Journal of postgraduate medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType 2 Diabetes Mellitus (T2DM) is a non insulin dependent, complex trait disease that develops due to genetic predisposition and environmental factors. The advanced stage in type 2 diabetes mellitus leads to several micro and macro vascular complications like nephropathy, neuropathy, retinopathy, heart related problems etc. Studies performed on the genetics, biochemistry and molecular biology of this disease to understand the pathophysiology of type 2 diabetes mellitus has led to the generation of a surfeit of data on candidate genes and related aspects. The research is highly progressive towards defining the exact etiology of this disease.
resultsT2D-Db (Type 2 diabetes Database) is a comprehensive web resource, which provides integrated and curated information on almost all known molecular components involved in the pathogenesis of type 2 diabetes mellitus in the three widely studied mammals namely human, mouse and rat. Information on candidate genes, SNPs (Single Nucleotide Polymorphism) in candidate genes or candidate regions, genome wide association studies (GWA), tissue specific gene expression patterns, EST (Expressed Sequence Tag) data, expression information from microarray data, pathways, protein-protein interactions and disease associated risk factors or complications have been structured in this on line resource.
conclusionInformation available in T2D-Db provides an integrated platform for the better molecular level understanding of type 2 diabetes mellitus and its pathogenesis. Importantly, the resource facilitates graphical presentation of the gene/genome wide map of SNP markers and protein-protein interaction networks, besides providing the heat map diagram of the selected gene(s) in an organism across microarray expression experiments from either single or multiple studies. These features aid to the data interpretation in an integrative way. T2D-Db is to our knowledge the first publicly available resource that can cater to the needs of researchers working on different aspects of type 2 diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.