ArticlePediatric nephrology (Berlin, Germany)2009
Vesicoureteral reflux, a benign condition.
Article in Pediatric nephrology (Berlin, Germany), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Evidence for and against urinary prophylaxis in vesicoureteral reflux.Pediatric nephrology (Berlin, Germany) · 2010Pooled it
- Primary vesicoureteral reflux.Nature reviews. Disease primers · 2024Review
- Application of contrast-enhanced ultrasound in the surgical treatment of vesicoureteral reflux in children.Pediatric surgery international · 2023Review
- Is ultrasonography mandatory in all children at their first febrile urinary tract infection?Pediatric nephrology (Berlin, Germany) · 2021Article
- Clinical Outcome of Children With Antenatally Diagnosed Hydronephrosis.Frontiers in pediatrics · 2019Review
- Contrast-enhanced voiding urosonography with intravesical administration of ultrasound contrast agent for the diagnosis of pediatric vesicoureteral reflux.Experimental and therapeutic medicine · 2018Article
- Estimation of the relationship between the polymorphisms of selected genes: ACE, AGTR1, TGFβ1 and GNB3 with the occurrence of primary vesicoureteral reflux.International urology and nephrology · 2017Article
- Vesicoureteral refux detection in children: a comparison of the midline-to-orifice distance measurement by ultrasound and voiding urosonography.Pediatric nephrology (Berlin, Germany) · 2016Article
- Insignificant impact of VUR on the progression of CKD in children with CAKUT.Pediatric nephrology (Berlin, Germany) · 2016Article
- Does prompt treatment of urinary tract infection in preschool children prevent renal scarring: mixed retrospective and prospective audits.Archives of disease in childhood · 2014Article
- Unrevealing of Primary Vesicoureteral Reflux which is Not Harmful for Kidneys in Children Should Be Considered as Success.Iranian journal of pediatrics · 2013Article
- NICE guidelines for imaging studies in children with UTI adequate only in boys under the age of 6 months.Pediatric surgery international · 2013Article
- [Primary vesicoureteral reflux].Der Urologe. Ausg. A · 2013Article
- Managing children under 36 months of age with febrile urinary tract infection: a new approach.Pediatric nephrology (Berlin, Germany) · 2012Article
- The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection.Journal of pediatric urology · 2012Article
- The demographics and costs of inpatient vesicoureteral reflux management in the USA.Pediatric nephrology (Berlin, Germany) · 2011Article
- Outcome and management of isolated severe renal pelvis dilatation detected at postnatal screening.Pediatric nephrology (Berlin, Germany) · 2010Article
- Urological problems or fecal continence during long-term follow-up of patients with anorectal malformation.Pediatric surgery international · 2010Article
- Catheter-free methods for vesicoureteric reflux detection: our experience and a critical appraisal of existing data.Pediatric nephrology (Berlin, Germany) · 2010Review
- Prevalence of renal anomalies after urinary tract infections in hospitalized infants less than 2 months of age.Journal of perinatology : official journal of the California Perinatal Association · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The combination of urinary tract infection (UTI) and vesicoureteral reflux (VUR) is commonly thought to predispose the child to pyelonephritis, renal scarring and, later in life, to hypertension or end-stage renal disease (ESRD). This paradigm has led to the active search, follow-up and treatment of VUR, and also prevention of recurrent UTI in children. The causality of VUR and ESRD is controversial, however. According to recent meta-analyses it is uncertain whether we can prevent renal scarring or ESRD by treating VUR. Studies on VUR are abundant, but the findings and conclusions are confounding. Because of the lack of evidence of the role of VUR, reasonable doubt has recently been presented on the rationale of imaging all children with UTI and treating the children with VUR. The overall importance of VUR is confounded because of the natural tendency of VUR to resolve spontaneously, its dynamic nature, and its different grades in children. The historical studies showing that VUR is much more common, even among healthy children, than usually claimed, have been forgotten. Since it seems that we are referring too many healthy children to unpleasant and possibly unnecessary imaging tests for VUR, we are uncertain when and what kind of VUR-if any-we should treat, and whether our present rationale of addressing VUR truly makes any difference to renal scarring or ESRD in children, we should critically revisit the subject of VUR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.