ArticleJournal of neuro-oncology2008
Correlation of MMP(1) and TIMP (1) expression with pituitary adenoma fibrosis.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Collagen in pituitary adenomas: A comprehensive review of biological roles and clinical implications.Journal of clinical & translational endocrinology · 2025Review
- Diffusion-weighted imaging for predicting tumor consistency and extent of resection in patients with pituitary adenoma.Neurosurgical review · 2021Article
- Tissue inhibitors of metalloproteinase-expressing cells in human anterior pituitary and pituitary adenoma.Medical molecular morphology · 2017Article
- Alterations of collagen-producing cells in human pituitary adenomas.Medical molecular morphology · 2016Article
- Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure.Odontology · 2016Article
- Relationship between pituitary adenoma texture and collagen content revealed by comparative study of MRI and pathology analysis.International journal of clinical and experimental medicine · 2015Article
- Parasellar T2 dark sign on MR imaging in patients with lymphocytic hypophysitis.AJNR. American journal of neuroradiology · 2010Article
- Clinicopathological characterization of TSH-producing adenomas: special reference to TSH-immunoreactive but clinically non-functioning adenomas.Endocrine pathology · 2009Article
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Authors and funding
9 authors.
Funding
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Abstract
objectiveTo explore the correlation of matrix metalloproteinase-1 (MMP(1)) and tissue inhibitor of metalloproteinase-1 (TIMP(1)) with pituitary adenoma fibrosis.
methodsThirty-eight pituitary adenoma specimens were divided into fibrous group (6 patients) and non-fibrous group (32 patients). MMP(1) and TIMP(1) expression was detected by RT-PCR and immunohistochemistry. The collagen content was determined by Sirius scarlet staining.
resultsIn fibrous and non-fibrous group: (1) the collagen content was 20.95 +/- 8.42% and 7.98 +/- 5.18% respectively, and there was a statistical significance (P < 0.01). (2) The expression of MMP(1)mRNA was 0.47 +/- 0.40 and 0.59 +/- 0.54 respectively and its protein expression was 0.12 +/- 0.09 and 0.13 +/- 0.09 respectively, and there was no statistical significance (P > 0.05). Their expression was not related to collagen content (P > 0.05). (3) The expression of TIMP(1)mRNA was 1.61 +/- 1.09 and 0.79 +/- 0.59 respectively and its protein expression was 0.58 +/- 0.11 and 0.32 +/- 0.18 respectively, and there was a statistical significance (P < 0.01). Their expression was related to collagen content (P < 0.01).
conclusionThe pathological features of pituitary adenoma fibrosis are excessive collagen deposition. High expression of TIMP(1) may be an important cause.
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