ArticleMediators of inflammation2008
Pro- and anti-inflammatory cytokines release in mice injected with Crotalus durissus terrificus venom.
Article in Mediators of inflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 48 citations in OpenAlex.
- Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation.PLoS neglected tropical diseases · 2013Trial
- A Possible Role for the Vagus Nerve in Physical and Mental Health.Biomolecules · 2026Review
- When Venom Meets the Heart: A Rare Case of Scorpion Sting-Induced Acute Myocardial Infarction.Cureus · 2023Article
- Pathophysiological and Clinical Significance ofToxins · 2023Article
- Pulmonary involvement from animal toxins: the cellular mechanisms.The journal of venomous animals and toxins including tropical diseases · 2023Article
- Review
- A novel activity on thymocytes cells exerted by the rattlesnake (Crotalus durissus cumanensis) venom.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Acute toxicity, antinociceptive, and anti-inflammatory activities of the orally administered crotamine in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Benefits of Sebastiania hispida (Euphorbiaceae) extract and photobiomodulation therapy as potentially adjunctive strategies to be explored against snake envenoming.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021Article
- Biomedical applications of snake venom: from basic science to autoimmunity and rheumatology.Journal of translational autoimmunity · 2021Review
- Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom.PloS one · 2020Article
- Effect ofToxins · 2018Article
- Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties.The journal of venomous animals and toxins including tropical diseases · 2018Review
- Crotalus durissus collilineatus Venom Induces TNF- α and IL-10 Production in Human Peripheral Blood Mononuclear Cells.ISRN inflammation · 2014Article
- Venomous snakebites in the Croatian North Dalmatia region.Wiener klinische Wochenschrift · 2011Article
- Inflammatory mediators release in urine from mice injected with Crotalus durissus terrificus venom.Mediators of inflammation · 2011Article
- Scorpion venom and the inflammatory response.Mediators of inflammation · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of Crotalus durissus terrificus venom (Cdt) were analyzed with respect to the susceptibility and the inflammatory mediators in an experimental model of severe envenomation. BALB/c female mice injected intraperitoneally presented sensibility to Cdt, with changes in specific signs, blood biochemical and inflammatory mediators. The venom induced reduction of glucose and urea levels and an increment of creatinine levels in serum from mice. Significant differences were observed in the time-course of mediator levels in sera from mice injected with Cdt. The maximum levels of IL-6, NO, IL-5, TNF, IL-4 and IL-10 were observed 15 min, 30 min, 1, 2 and 4 hours post-injection, respectively. No difference was observed for levels of IFN-gamma. Taken together, these data indicate that the envenomation by Cdt is regulated both pro- and anti-inflammatory cytokine responses at time-dependent manner. In serum from mice injected with Cdt at the two first hours revealed of pro-inflammatory dominance. However, with an increment of time an increase of anti-inflammatory cytokines was observed and the balance toward to anti-inflammatory dominance. In conclusion, the observation that Cdt affects the production of pro- and anti-inflammatory cytokines provides further evidence for the role played by Cdt in modulating pro/anti-inflammatory cytokine balance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.