ArticleNeural plasticity2008
Effect of prenatal protein malnutrition on long-term potentiation and BDNF protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization.
Article in Neural plasticity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 34 citations in OpenAlex.
- Prenatal protein deficiency causes age-specific alteration in number and distribution of inhibitory neurons in the somatosensory cortex during early postnatal development.Journal of biosciences · 2025Article
- Paternal methamphetamine exposure induces higher sensitivity to methamphetamine in male offspring through driving ADRB1 on CaMKII-positive neurons in mPFC.Translational psychiatry · 2023Article
- The neural basis of attentional alterations in prenatally protein malnourished rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Article
- Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring.The Journal of nutritional biochemistry · 2017Article
- Physiological slowing and upregulation of inhibition in cortex are correlated with behavioral deficits in protein malnourished rats.PloS one · 2013Article
- Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduction of the protein content from 25 to 8% casein in the diet of pregnant rats results in impaired neocortical long-term potentiation (LTP) of the offspring together with lower visuospatial memory performance. The present study was aimed to investigate whether this type of maternal malnutrition could result in modification of plastic capabilities of the entorhinal cortex (EC) in the adult progeny. Unlike normal eutrophic controls, 55-60-day-old prenatally malnourished rats were unable to develop LTP in the medial EC to tetanizing stimulation delivered to either the ipsilateral occipital cortex or the CA1 hippocampal region. Tetanizing stimulation of CA1 also failed to increase the concentration of brain-derived neurotrophic factor (BDNF) in the EC of malnourished rats. Impaired capacity of the EC of prenatally malnourished rats to develop LTP and to increase BDNF levels during adulthood may be an important factor contributing to deficits in learning performance having adult prenatally malnourished animals.
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