ArticlePLoS computational biology2008
Kinetic modeling of the assembly, dynamic steady state, and contraction of the FtsZ ring in prokaryotic cytokinesis.
Article in PLoS computational biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 47 citations in OpenAlex.
- Data integration strategies for whole-cell modeling.FEMS yeast research · 2024Review
- A stochastic model for dynamics of FtsZ filaments and the formation of Z -ring.The European physical journal. E, Soft matter · 2020Article
- Insights into the Structure, Function, and Dynamics of the Bacterial Cytokinetic FtsZ-Ring.Annual review of biophysics · 2020Review
- Efficient models of polymerization applied to FtsZ ring assembly inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Beyond force generation: Why is a dynamic ring of FtsZ polymers essential for bacterial cytokinesis?BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Redefining the roles of the FtsZ-ring in bacterial cytokinesis.Current opinion in microbiology · 2016Review
- Efficient Multiscale Models of Polymer Assembly.Biophysical journal · 2016Article
- Defining the rate-limiting processes of bacterial cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- FtsZ filament capping by MciZ, a developmental regulator of bacterial division.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bacterial cell division: experimental and theoretical approaches to the divisome.Science progress · 2015Review
- An equilibrium model for the Mg(2+)-linked self-assembly of FtsZ in the presence of GTP or a GTP analogue.Biochemistry · 2012Article
- Depolymerization dynamics of individual filaments of bacterial cytoskeletal protein FtsZ.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Inside-out Z rings--constriction with and without GTP hydrolysis.Molecular microbiology · 2011Article
- FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.Microbiology and molecular biology reviews : MMBR · 2010Review
- Simple modeling of FtsZ polymers on flat and curved surfaces: correlation with experimental in vitro observations.PMC biophysics · 2009Article
- FtsZ filament dynamics at steady state: subunit exchange with and without nucleotide hydrolysis.Biochemistry · 2009Article
- Modeling the physics of FtsZ assembly and force generation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Force generation by a dynamic Z-ring in Escherichia coli cell division.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinesis in prokaryotes involves the assembly of a polymeric ring composed of FtsZ protein monomeric units. The Z ring forms at the division plane and is attached to the membrane. After assembly, it maintains a stable yet dynamic steady state. Once induced, the ring contracts and the membrane constricts. In this work, we present a computational deterministic biochemical model exhibiting this behavior. The model is based on biochemical features of FtsZ known from in vitro studies, and it quantitatively reproduces relevant in vitro data. An essential part of the model is a consideration of interfacial reactions involving the cytosol volume, where monomeric FtsZ is dispersed, and the membrane surface in the cell's mid-zone where the ring is assembled. This approach allows the same chemical model to simulate either in vitro or in vivo conditions by adjusting only two geometrical parameters. The model includes minimal reactions, components, and assumptions, yet is able to reproduce sought-after in vivo behavior, including the rapid assembly of the ring via FtsZ-polymerization, the formation of a dynamic steady state in which GTP hydrolysis leads to the exchange of monomeric subunits between cytoplasm and the ring, and finally the induced contraction of the ring. The model gives a quantitative estimate for coupling between the rate of GTP hydrolysis and of FtsZ subunit turnover between the assembled ring and the cytoplasmic pool as observed. Membrane constriction is chemically driven by the strong tendency of GTP-bound FtsZ to self-assembly. The model suggests a possible mechanism of membrane contraction without a motor protein. The portion of the free energy of GTP hydrolysis released in cyclization is indirectly used in this energetically unfavorable process. The model provides a limit to the mechanistic complexity required to mimic ring behavior, and it highlights the importance of parallel in vitro and in vivo modeling.
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