ArticleEvidence-based complementary and alternative medicine : eCAM2008
Cytoprotective Activity of Glycyrrhizae radix Extract Against Arsenite-induced Cytotoxicity.
Article in Evidence-based complementary and alternative medicine : eCAM, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
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- Blockade of nicotine sensitization by methanol extracts of Glycyrrhizae radix mediated via antagonism of accumbal oxidative stress.BMC complementary and alternative medicine · 2017Article
- Cytotoxic and apoptotic effects of Ebenus boissieri Barbey on human lung cancer cell line A549.Pharmacognosy magazine · 2015Article
- Isolation and bioactivities of the flavonoids morin and morin-3-O-β-D-glucopyranoside from Acridocarpus orientalis-A wild Arabian medicinal plant.Molecules (Basel, Switzerland) · 2014Article
- Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines.Journal of ethnopharmacology · 2013Article
- Cytotoxic effects of bangladeshi medicinal plant extracts.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Caspase-mediated Apoptotic Effects ofPharmacognosy magazineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Licorice, Glycyrrhizae radix, is one of the herbal medicines in East Asia that has been commonly used for treating various diseases, including stomach disorders. This study investigated the effect of licorice on arsenite (As)-induced cytotoxicity in H4IIE cells, a rat hepatocyte-derived cell line. Cell viability was significantly diminished in As-treated H4IIE cells in a time and concentration-dependent manner. Furthermore, results from flow cytometric assay and DNA laddering in H4IIE cells showed that As treatment induced apoptotic cell death by activating caspase-3. Licorice (0.1 and 1.0 mg ml(-1)) treatment significantly inhibited cell death and the activity of caspase-3 in response to As exposure. These results demonstrate that licorice induced a cytoprotective effect against As-induced cell death by inhibition of caspase-3.
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