Evidence map›Paper›PMID 18604247›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2008

Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers.

Ying Liu, Yasushi Fukuwatari, Ko Okumura, Kazuyoshi Takeda, Ken-Ichi Ishibashi, Mai Furukawa, Naohito Ohno, Kazu Mori, Ming Gao, Masuro Motoi

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Foods (Basel, Switzerland) · 2019
    Article
  3. Influence of the Culture Substrate on thePlants (Basel, Switzerland) · 2019
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  4. Effects ofNutrients · 2019
    Article
  5. Article
  6. Evidence-based complementary and alternative medicine : eCAM · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Immunomodulating compounds in Basidiomycetes.Journal of clinical biochemistry and nutrition · 2013
    Article
  12. Agaricus subrufescens: A review.Saudi journal of biological sciences · 2012
    Article
  13. Article
  14. Article
  15. Production flush of Agaricus blazei on Brazilian casing layers.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011
    Article
  16. Article
  17. Antioxidant Activity of Agaricus brasiliensis Basidiocarps on Different Maturation Phases.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011
    Article
  18. Article
  19. Article
  20. Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ying LiuMibyou Medical Research Center, Institute of Preventive Medicine, Tokyo, Japan Department of Immunology, School of Medicine, Juntendo University School of Medicine, Tokyo, Japan Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan Department of Acupuncture and Moxibustion, Suzuka University of Medical Science and Mie, Japan, and Toei Pharmaceutical Co., Ltd., Tokyo, Japan.
Yasushi Fukuwatari
Ko Okumura
Kazuyoshi Takeda
Ken-Ichi Ishibashi
Mai Furukawa
Naohito Ohno
Kazu Mori
Ming Gao
Masuro Motoi
Tokyo University of Pharmacy and Life Sciences · JPJuntendo University · JPSuzuka University of Medical Science · JPResearch Institute of Therapy and Preventive Medicine · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed studies on murine models and human volunteers to examine the immunoenhancing effects of the naturally outdoor-cultivated fruit body of Agaricus brasiliensis KA21 (i.e. Agaricus blazei). Antitumor, leukocyte-enhancing, hepatopathy-alleviating and endotoxin shock-alleviating effects were found in mice. In the human study, percentage body fat, percentage visceral fat, blood cholesterol level and blood glucose level were decreased, and natural killer cell activity was increased. Taken together, the results strongly suggest that the A. brasiliensis fruit body is useful as a health-promoting food.

Indexed as

A. brasiliensisclinical researchcold water extractNK activityoutdoor-cultivatedsafety

Identifiers

PMID18604247
PMCPMC2396466
OpenAlexW2130919231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.