ArticleBritish journal of pharmacology2008
Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
Article in British journal of pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Effect of single doses of citalopram and reboxetine on urethral pressure: A randomized, double-blind, placebo- and active-controlled three-period crossover study in healthy women.Neurourology and urodynamics · 2022Trial
- Serum Serotonin Levels as a Potential Risk Factor for Overactive Bladder in a Community-Dwelling Population: A Four-Year Longitudinal Study.Lower urinary tract symptoms · 2025Article
- Urethral pharmacological mechanisms incontinence and bladder emptying: An updated review.Bladder (San Francisco, Calif.) · 2024Review
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- Fluoxetine Related Urinary Retention in a 15-Year-Old Girl: a Case Report.Noro psikiyatri arsivi · 2022Article
- Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Delivery of the 5-HTBiology · 2021Article
- The association between serum serotonin levels and overactive bladder: results from a community-based cross-sectional study in Japan.World journal of urology · 2021Article
- Urinary incontinence associated with anxiety and depression: the impact of psychotropic drugs in a cross-sectional study from the Norwegian HUNT study.BMC psychiatry · 2020Article
- Development of Cardiovascular Dysfunction in a Rat Spinal Cord Crush Model and Responses to Serotonergic Interventions.Journal of neurotrauma · 2019Article
- An Additive Mix? Acute Urinary Retention in a Patient With Benign Prostatic Hyperplasia Treated With Suboxone, Lurasidone, and Trazodone.Focus (American Psychiatric Publishing) · 2018Article
- Chemosensory epithelial cells in the urethra: sentinels of the urinary tract.Histochemistry and cell biology · 2016Review
- Effect of 5-HT7 receptor agonist, LP-211, on micturition following spinal cord injury in male rats.American journal of translational research · 2016Article
- Treatment of monosymptomatic nocturnal enuresis: sertraline for non-responders to desmopressin.Iranian journal of medical sciences · 2014Article
- Is there a correlation between intravaginal ejaculatory latency time and enuresis? An exploratory study.Central European journal of urology · 2014Article
- Effect of methysergide on pudendal inhibition of micturition reflex in cats.Experimental neurology · 2013Article
- A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy.British journal of pharmacology · 2011Article
- External urethral sphincter motoneuron properties in adult female rats studied in vitro.Journal of neurophysiology · 2010Article
- Neural control of the female urethral and anal rhabdosphincters and pelvic floor muscles.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeMicturition is controlled by central 5-HT-containing pathways. 5-HT2 receptors have been implicated in this system especially in control of the urethra, which is a drug target for treating urinary incontinence. This study investigates the role of each of the three subtypes of this receptor with emphasis on sphincter regulation. EXPERIMENTAL APPROACH: Recordings of urethral and bladder pressure, external urethral sphincter (EUS) EMG, as well as the micturition reflex induced by bladder distension along with blood pressure and heart rate were made in anaesthetized rats. The effects of agonists and antagonists for 5-HT2 receptor subtypes were studied on these variables. KEY
resultsThe 5-HT2C agonists Ro 60-0175, WAY 161503 and mCPP, i.v., activated the EUS, increased urethral pressure and inhibited the micturition reflex. The effects of Ro 60-0175 on the EUS were blocked by the 5-HT2C antagonist SB 242084 and the 5-HT2A antagonists, ketanserin and MDL 100907. SB 242084 also blocked the inhibitory action on the reflex, while the 5-HT2B antagonist RS 127445 only blocked the increase in urethral pressure. The 5-HT2A receptor agonist DOI given i.v. or i.t. but not i.c.v. activated the EUS. CONCLUSIONS AND IMPLICATIONS: 5-HT2A/2C receptors located in the sacral spinal cord activate the EUS, while central 5-HT2C receptors inhibit the micturition reflex and 5-HT2B receptors, probably at the level of the urethra, increase urethral smooth muscle tone. Furthermore, 5-HT2B and 5-HT2C receptors do not seem to play an important role in the physiological regulation of micturition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.