ReviewCell cycle (Georgetown, Tex.)2008
Melanomagenesis: overcoming the barrier of melanocyte senescence.
Review in Cell cycle (Georgetown, Tex.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Putrescine Upregulates Melanogenesis Through Modulation of MITF Transcription Factor in B16F1 Mouse Melanoma Cells.Food technology and biotechnology · 2024Article
- Review: The Key Factors to Melanomagenesis.Life (Basel, Switzerland) · 2023Review
- Article
- Loss of Both CDKN2A and CDKN2B Allows for Centrosome Overduplication in Melanoma.The Journal of investigative dermatology · 2020Article
- Acquired resistance to BRAFi reverses senescence-like phenotype in mutant BRAF melanoma.Oncotarget · 2018Article
- Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts.The international journal of biochemistry & cell biology · 2016Article
- Phytochemicals for the Management of Melanoma.Mini reviews in medicinal chemistry · 2016Review
- Rapamycin induces pluripotent genes associated with avoidance of replicative senescence.Cell cycle (Georgetown, Tex.) · 2013Article
- MC1R is a potent regulator of PTEN after UV exposure in melanocytes.Molecular cell · 2013Article
- Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression.Pigment cell & melanoma research · 2013Article
- Article
- Collagen XVII is expressed in malignant but not in benign melanocytic tumors and it can mediate antibody induced melanoma apoptosis.Histochemistry and cell biology · 2012Article
- Shorter telomeres associate with a reduced risk of melanoma development.Cancer research · 2011Article
- Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression.Pigment cell & melanoma research · 2011Article
- Pirin inhibits cellular senescence in melanocytic cells.The American journal of pathology · 2011Article
- Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence.Cancer research · 2010Article
- Novel primate-specific genes, RMEL 1, 2 and 3, with highly restricted expression in melanoma, assessed by new data mining tool.PloS one · 2010Article
- Expression of coxsackie and adenovirus receptor distinguishes transitional cancer states in therapy-induced cellular senescence.Cell death & disease · 2010Article
- Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma.Genes, chromosomes & cancer · 2010Article
- Inside life of melanoma cell signaling, molecular insights, and therapeutic targets.Current oncology reports · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Although melanoma ultimately progresses to a highly aggressive and metastatic disease that is typically resistant to currently available therapy, it often begins as a benign nevus consisting of a clonal population of hyperplastic melanocytes that cannot progress because they are locked in a state of cellular senescence. Once senescence is overcome, the nevus can exhibit dysplastic features and readily progress to more lethal stages. Recent advances have convincingly demonstrated that senescence represents a true barrier to the progression of many types of cancer, including melanoma. Thus, understanding the mechanism(s) by which melanoma evades senescence has become a priority in the melanoma research community. Senescence in most cells is regulated through some combination of activities within the RB and p53 pathways. However, differences discovered among various tumor types, some subtle and others quite profound, have revealed that senescence frequently operates in a context-dependent manner. Here we review what is known about melanocyte senescence, and how such knowledge may provide a much-needed edge in our struggles to contain or perhaps vanquish this often-fatal malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.