ArticleHaematologica2008
Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome.
Article in Haematologica, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The Coming of Age of Preclinical Models of MDS.Frontiers in oncology · 2022Pooled it
- Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis.Disease models & mechanisms · 2022Article
- TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.Experimental hematology · 2020Article
- HoxA9 binds and represses the Cebpa +8 kb enhancer.PloS one · 2019Article
- Article
- Altered follicular helper T cell impaired antibody production in a murine model of myelodysplastic syndromes.Oncotarget · 2017Article
- Article
- Stem cell origin of myelodysplastic syndromes.Oncogene · 2014Review
- Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome.Leukemia research · 2014Article
- Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.The Journal of experimental medicine · 2013Article
- Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Haematologica · 2013Review
- Article
- NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.Blood · 2011Review
- Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer.Genome research · 2010Article
- Mouse models of myelodysplastic syndromes.Hematology/oncology clinics of North America · 2010Review
- Unimpaired terminal erythroid differentiation and preserved enucleation capacity in myelodysplastic 5q(del) clones: a single cell study.Haematologica · 2010Article
- Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of a NUP98-HOXD13 (NHD13) fusion gene, initially identified in a patient with myelodysplastic syndrome, leads to a highly penetrant myelodysplastic syndrome in mice that recapitulates all of the key features of the human disease. Expansion of undifferentiated lineage negative (lin(neg)) hematopoietic precursors that express NHD13 was markedly inhibited (30-fold) in vitro. Decreased expansion was accompanied by decreased production of terminally differentiated cells, indicating impaired differentiation of NHD13 precursors. Rather than differentiate, the majority (80%) of NHD13 lin(neg) precursors underwent apoptotic cell death when induced to differentiate. These findings demonstrate that NHD13 lin(neg) cells provide a tractable in vitro system for studies of myelodysplastic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.