ArticleInternational journal of cardiology2009
Reduction in alpha-adrenergic receptor-mediated vascular tone contributes to improved arterial compliance with endurance training.
Article in International journal of cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Effects of aquatic exercise on arterial stiffness and endothelial function in adults: A systematic review and meta-analyses.PloS one · 2025Pooled it
- The Effects of High-Intensity Interval Training on Cardiometabolic Health in Children and Adolescents: A Systematic Review and Meta-Analysis.Journal of sports science & medicine · 2024Pooled it
- The Efficacy of Stretching Exercises on Arterial Stiffness in Middle-Aged and Older Adults: A Meta-Analysis of Randomized and Non-Randomized Controlled Trials.International journal of environmental research and public health · 2020Pooled it
- Aerobic exercise training reduces cerebrovascular impedance in older adults: a 1-year randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor κ B signalling.Journal of hypertension · 2015Trial
- Aerobic training-induced improvements in arterial stiffness are not sustained in older adults with multiple cardiovascular risk factors.Journal of human hypertension · 2013Trial
- Effects of acute cervical stretching on arterial wall elastic properties.Frontiers in physiology · 2023Article
- Regular exercise ball training reduces arterial stiffness in sedentary middle-aged males.Journal of physical therapy science · 2022Article
- Genetic Profile in Genes Associated with Cardiorespiratory Fitness in Elite Spanish Male Endurance Athletes.Genes · 2021Article
- Impact of acute mental stress on segmental arterial stiffness.European journal of applied physiology · 2020Article
- Middle-aged endurance athletes exhibit lower cerebrovascular impedance than sedentary peers.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- The effects of exercise on vascular markers and C-reactive protein among obese children and adolescents: An evidence-based review.Bosnian journal of basic medical sciences · 2020Review
- The Effect of Head-Out Aquatic Exercise on Arterial Stiffness in Middle-Aged and Elderly People.Pulse (Basel, Switzerland) · 2020Article
- Dose of Alcohol From Beer Required for Acute Reduction in Arterial Stiffness.Frontiers in physiology · 2020Article
- Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Habitual physical activity and central artery stiffening in older adults: the Atherosclerosis Risk in Communities study.Journal of hypertension · 2018Article
- Arterial stiffness in young adult swimmers.European journal of applied physiology · 2017Article
- Greater Progression of Age-Related Aortic Stiffening in Adults with Poor Trunk Flexibility: A 5-Year Longitudinal Study.Frontiers in physiology · 2017Article
- A mathematical model of coronary blood flow control: simulation of patient-specific three-dimensional hemodynamics during exercise.American journal of physiology. Heart and circulatory physiology · 2016Article
- Four weeks of regular static stretching reduces arterial stiffness in middle-aged men.SpringerPlus · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRegular aerobic exercise improves large artery compliance in middle-aged and older humans. However, the underlying mechanisms are unknown. We tested the hypothesis that the improved central arterial compliance with endurance training is mediated by decreased alpha-adrenergic tone and/or increased endothelial function.
methodsSeven sedentary healthy adults (60+/-3 years) underwent systemic alpha-adrenergic blockade (phentolamine) and nitric oxide synthase (NOS) inhibition using N(G)-monomethyl-L-arginine in sequence before and after a 3-month moderate endurance training (walk/jog, 4-5 days/week). Phentolamine was given first to isolate the contribution of nitric oxide to arterial compliance by minimizing reflex suppression of sympathetic tone resulting from systemic NOS inhibition as well as to assess the alpha-adrenergic receptor-mediated modulation of arterial compliance.
resultsBaseline arterial compliance (via simultaneous ultrasound and applanation tonometry on the carotid artery) increased 34+/-12% after exercise training (P<0.01). When alpha-adrenergic blockade was performed, arterial compliance increased 37+/-6% (P<0.01) before the exercise training but did not change significantly after the training. Decreases in arterial compliance from the alpha-adrenergic blockade to the subsequent additional NOS blockade were not different before and after exercise training.
conclusionOur results suggest that the reduction in alpha-adrenergic receptor-mediated vascular tone contributes to the improved central arterial compliance with endurance training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.