ArticleMethods in enzymology2008
A mouse mammary epithelial cell model to identify molecular mechanisms regulating breast cancer progression.
Article in Methods in enzymology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Peripubertal high-fat diet promotes c-Myc stabilization in mammary gland epithelium.Cancer science · 2020Article
- Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice.PLoS genetics · 2019Article
- Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis.Nature cell biology · 2017Article
- Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways.Oncogene · 2015Article
- Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells.Breast cancer research and treatment · 2015Article
- ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.Nature cell biology · 2014Article
- Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity.The Journal of biological chemistry · 2014Article
- ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss.Autophagy · 2014Article
- Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.Oncogene · 2014Article
- P21 activated kinases: structure, regulation, and functions.Small GTPases · 2014Review
- Bovine mammary epithelial cell cultures for the study of mammary gland functions.In vitro cellular & developmental biology. Animal · 2014Article
- The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells.Oncogenesis · 2013Article
- PAK4-6 in cancer and neuronal development.Cellular logistics · 2012Article
- The pak4 protein kinase in breast cancer.ISRN oncology · 2012Article
- Article
- Autophagy as a therapeutic target in cancer.Cancer biology & therapy · 2011Review
- Review
- The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis.Oncogene · 2010Article
- Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors.Molecular cancer research : MCR · 2010Article
- Animal models of breast cancer for the study of pathogenesis and therapeutic insights.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Breast cancer, like any other human cancer, results from the accumulation of mutations that deregulate critical cellular processes, such as cell proliferation and death. Activation of oncogenes and inactivation of tumor suppressor genes are common events during cancer initiation and progression and often determine treatment responsiveness. Thus, recapitulating these events in mouse cancer models is critical for unraveling the molecular mechanisms involved in tumorigenesis and for interrogating their possible impact on response to anticancer drugs. We have developed a novel mouse mammary epithelial cell model, which replicates the steps of epithelial tumor progression and takes advantage of the power of mouse genetics and the ability to assess three-dimensional morphogenesis in the presence of extracellular matrix to model human breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.