ArticleMethods (San Diego, Calif.)2008
Using molecular tethering to analyze the role of nuclear compartmentalization in the regulation of mammalian gene activity.
Article in Methods (San Diego, Calif.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Subnuclear localisation is associated with gene expression more than parental origin at the imprinted Dlk1-Dio3 locus.PLoS genetics · 2022Article
- Histone methyltransferase activity programs nuclear peripheral genome positioning.Developmental biology · 2020Article
- Chromatin states and nuclear organization in development--a view from the nuclear lamina.Genome biology · 2015Review
- Expression of the DYRK1A gene correlates with its 3D positioning in the interphase nucleus of Down syndrome cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Article
- Nuclear envelope and genome interactions in cell fate.Frontiers in genetics · 2015Review
- Article
- The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response.Oncogene · 2012Article
- Article
- Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation.PloS one · 2010Article
- Overcoming uncertainty through advances in fluorescence imaging of molecular processes in cells.Methods (San Diego, Calif.) · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The mammalian nucleus has a complex structural organization that dynamically interacts with the genome. Chromatin is organized into discrete domains by association with distinct nuclear compartments enriched in structural and regulatory proteins. Growing evidence suggests that gene activity is modulated by interactions with these sub-nuclear compartments. Therefore, analyzing how nuclear architecture controls genome activity will be necessary to fully understand complex biological processes such as development and disease. In this article we describe a molecular methodology involving inducible tethering that can be used to position genes at the inner nuclear membrane (INM)-lamina compartment. The consequences of such directed re-positioning on gene activity or other DNA transactions can then be analyzed. This approach can be generalized and extended to position genes or chromosomal domains within other nuclear compartments thereby greatly facilitating the analysis of nuclear structure and its impact on genome activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.