Trial reportThe Journal of nutritional biochemistry2009
Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults.
Trial report in The Journal of nutritional biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- A phase 2 cancer chemoprevention biomarker trial of isoflavone G-2535 (genistein) in presurgical bladder cancer patients.Cancer prevention research (Philadelphia, Pa.) · 2012Trial
- The volume of nipple aspirate fluid is not affected by 6 months of treatment with soy foods in premenopausal women.The Journal of nutrition · 2011Trial
- Disposition of hop prenylflavonoids in human breast tissue.Molecular nutrition & food research · 2010Trial
- Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation.The Prostate · 2009Trial
- Genistein supplementation attenuates arsenic-triggered neurobehavioral deficits and ER stress-associated gene dysregulation in Nile tilapia.Fish physiology and biochemistry · 2025Article
- The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential.Molecules (Basel, Switzerland) · 2025Review
- Review
- Traditional and Domestic Cooking Dramatically Reduce Estrogenic Isoflavones in Soy Foods.Foods (Basel, Switzerland) · 2024Article
- Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs.Turkish journal of pharmaceutical sciences · 2021Article
- The Role of Dietary Phytoestrogens and the Nuclear Receptor PPARγ in Adipogenesis: An in Vitro Study.Environmental health perspectives · 2019Article
- Low dietary soy isoflavonoids increase hippocampal spine synapse density in ovariectomized rats.Brain research · 2017Article
- Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein Transporter.The Journal of pharmacology and experimental therapeutics · 2016Article
- Soy and the soy isoflavone genistein promote adipose tissue development in male mice on a low-fat diet.European journal of nutrition · 2015Article
- Effects of Tomato and Soy Germ on Lipid Bioaccumulation and Atherosclerosis in ApoE-/- Mice.Journal of food science · 2015Article
- Genistein as a nature-derived PPAR agonist in adipogenesis and weight gain.European journal of nutrition · 2015Article
- Sex hormone modulation of both induction and inhibition of CYP1A by genistein in HepG2/C3A cells.In vitro cellular & developmental biology. Animal · 2015Article
- Interaction of Isoflavones with the BCRP/ABCG2 Drug Transporter.Current drug metabolism · 2015Review
- In vivo anti-fatigue activity of sufu with fortification of isoflavones.Pharmacognosy magazine · 2014Article
- Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells.Journal of nutrition and metabolism · 2013Article
- Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats.Hormones and behavior · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of this investigation was to examine the pharmacokinetics of isoflavone concentrations over a 24-h period among healthy adults consuming either soy foods or soy isoflavone tablets at different doses. This randomized, cross-over trial was conducted with 12 generally healthy adults. The three phases of the intervention included isoflavone tablets at (1) 144 mg/day or (2) 288 mg/day and (3) soy foods designed to provide a calculated 96 mg isoflavones/day (doses in aglycone equivalents). Doses were spread out over three meals per day. After 6 days on each study phase, plasma isoflavone concentrations were determined on the seventh day at 0, 4, 8, 10, 12 and 24 h. Average levels of total isoflavone concentrations at 8, 10 and 12 h were >4 micromol/L for the soy food phase and for the higher dose tablet phase. Genistein concentrations were higher overall in the soy food vs. both the lower and the higher dose supplement phases of the study (P<.05). When comparing plasma concentrations for the two doses of tablets, saturation appeared more evident for genistein than for daidzein at the higher dose level. In conclusion, we observed important differences in the pharmacokinetics of genistein and daidzein contrasting the sources and doses of isoflavones when administered three times daily, including a possible advantage for increasing serum concentrations of isoflavones from consuming soy foods relative to isoflavone supplements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.