ArticleBiochemical and biophysical research communications2008
Protein kinase D1 (PKD1) influences androgen receptor (AR) function in prostate cancer cells.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- miR-410 Is a Key Regulator of Epithelial-to-Mesenchymal Transition with Biphasic Role in Prostate Cancer.Cancers · 2023Article
- Potential role for protein kinase D inhibitors in prostate cancer.Journal of molecular medicine (Berlin, Germany) · 2023Review
- Chemopreventive Potential of Dietary Nanonutraceuticals for Prostate Cancer: An Extensive Review.Frontiers in oncology · 2022Review
- Identification of potential key genes and high-frequency mutant genes in prostate cancer by using RNA-Seq data.Oncology letters · 2018Article
- Article
- Protein kinase D1 regulates subcellular localisation and metastatic function of metastasis-associated protein 1.British journal of cancer · 2018Article
- Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer.Oncotarget · 2017Article
- Protein kinase D signaling in cancer: A friend or foe?Biochimica et biophysica acta. Reviews on cancer · 2017Review
- Protein Kinase D: A Potential Therapeutic Target in Prostate Cancer.Molecular and cellular pharmacology · 2017Article
- Cell line modeling to study biomarker panel in prostate cancer.The Prostate · 2016Article
- Article
- Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer.Biomaterials · 2014Article
- Protein kinase D1 attenuates tumorigenesis in colon cancer by modulating β-catenin/T cell factor activity.Oncotarget · 2014Article
- Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4.The Biochemical journal · 2013Article
- In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.Cancer chemotherapy and pharmacology · 2013Article
- Inducible silencing of protein kinase D3 inhibits secretion of tumor-promoting factors in prostate cancer.Molecular cancer therapeutics · 2012Article
- Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1.PloS one · 2012Article
- Emerging roles of protein kinase D1 in cancer.Molecular cancer research : MCR · 2011Review
- Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation.Neuro-oncology · 2011Article
- Protein kinase D as a potential new target for cancer therapy.Biochimica et biophysica acta · 2010Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Protein kinase D1 (PKD1), founding member of PKD protein family, is down-regulated in advanced prostate cancer (PCa). We demonstrate that PKD1 and androgen receptor (AR) are present as a protein complex in PCa cells. PKD1 is associated with a transcriptional complex which contains AR and promoter sequence of the Prostate Specific Antigen (PSA) gene. Ectopic expression of wild type PKD1 and the kinase dead mutant PKD1 (K628W) attenuated the ligand-dependent transcriptional activation of AR in prostate cancer cells and yeast cells indicating that PKD1 can affect AR transcription activity, whereas knocking down PKD1 enhanced the ligand-dependent transcriptional activation of AR. Co-expression of kinase dead mutant with AR significantly inhibited androgen-mediated cell proliferation in both LNCaP and DU145 PC cells. Our data demonstrate for the first time that PKD1 can influence AR function in PCa cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.