Evidence map›Paper›PMID 18602326›Full record

ArticleJournal of feline medicine and surgery2008

Glucose lowering effects of inhaled insulin in healthy cats.

Amy E DeClue, Elizabeth F Leverenz, Charles E Wiedmeyer, Margaret E Bryan, Carol R Reinero

Open access · greenAbstract read
In one paragraph

Article in Journal of feline medicine and surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Amy E DeClueDepartment of Veterinary Medicine and Surgery, University of Missouri-College of Veterinary Medicine, 900 East Campus Drive, Columbia, MO 65211, USA. decluea@missouri.edu
Elizabeth F Leverenz
Charles E Wiedmeyer
Margaret E Bryan
Carol R Reinero
University of Missouri · USMissouri College · USWashington State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhaled medications have proven effective and well tolerated in cats, and inhaled insulin has been used successfully for the management of diabetes mellitus in humans. Thus, we hypothesize that delivery of aerosolized regular insulin can lower blood glucose in healthy cats. Five adult cats were administered aerosolized 0.9% saline (IS), regular insulin intravenously (IV) 0.5 U/kg, and aerosolized regular insulin 15 U/kg (I15) and 25 U/kg (I25) and blood glucose was evaluated. Mean blood glucose was significantly lower at 15, 30 and 45 min in the I25 and IV groups compared to baseline. Similarly, the IV and I25 groups had a significantly greater maximal percent change in blood glucose than the IS group. Significantly more cats developed severe hypoglycemia (<50 mg/dl; 2.7 mmol/l) in the IV and I25 groups than in the IS group. Results of this study demonstrate that aerosolized insulin can effectively lower blood glucose concentrations in healthy cats.

Indexed as

Administration, InhalationAerosolsAnimalsArea Under CurveBlood GlucoseCat DiseasesCatsCross-Over StudiesDiabetes MellitusHypoglycemic AgentsInjections, IntravenousInsulinRandom AllocationSpecific Pathogen-Free OrganismsTreatment OutcomeAerosolsBlood GlucoseHypoglycemic AgentsInsulin

Identifiers

PMID18602326
PMCPMC11271233
OpenAlexW2062730478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.