Evidence map›Paper›PMID 18602166›Full record

ArticleJournal of neuroimmunology2008

CCL genes in multiple sclerosis and systemic lupus erythematosus.

Tamara Vyshkina, Andrew Sylvester, Saud Sadiq, Eduardo Bonilla, Andras Perl, Bernadette Kalman

Open access · greenAbstract read
In one paragraph

Article in Journal of neuroimmunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Gene expression in thiazide diuretic or statin users in relation to incident type 2 diabetes.International journal of molecular epidemiology and genetics · 2014
    Article
  11. Single-nucleotide polymorphisms in genes encoding for CC chemokines were not associated with the risk of non-Hodgkin lymphoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tamara VyshkinaVAMC Research, 800. Irving Avenue, Syracuse, NY 13210, United States.
Andrew Sylvester
Saud Sadiq
Eduardo Bonilla
Andras Perl
Bernadette Kalman
SUNY Upstate Medical University · USMultiple Sclerosis Center Of Northeastern New York · USSyracuse VA Medical Center · US

Funding

Metabolic Control of T-cell Lineage Specification in SLER01AI072648 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2008 to 2024
$6.1M
IMPACT OF HRES-1 ENDOGENOUS RETROVIRUS IN SLER01AI048079 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2000 to 2013
$2.7M
Genetic and Immunological Impact of the HRES-1/Rab4 Locus in SLER56AI048079 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2008 to 2008
$275k
Mitochondrial dysfunction in patients with SLER21AI061066 · NIAID · UPSTATE MEDICAL UNIVERSITY · PI PERL, ANDRAS · 2004 to 2004
$266k
NIAID NIH HHS AI 048079NIAID NIH HHS AI 061066NIAID NIH HHS AI 072648NIAID NIH HHS R01 AI048079NIAID NIH HHS R01 AI072648NIAID NIH HHS R21 AI061066NIAID NIH HHS R56 AI048079
6 · The paper itself

Abstract

This follow up study aims to refine the roles of previously suggested candidate genes (CC chemokine ligands or CCLs) in multiple sclerosis (MS), and to test these markers in another autoimmune disorder, systemic lupus erythematosus (SLE). After stringent correction for multiple testing, we reject the importance of previously suggested borderline associations with CCLs in MS. A new finding is the differential distribution of CCL8 marker alleles and a haplotype in extreme severity subgroups of MS. In SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype.

Indexed as

Genetic Predisposition to DiseaseAdultChemokines, CCDNA Mutational AnalysisFemaleFollow-Up StudiesGene FrequencyGenotypeHumansLupus Erythematosus, SystemicMaleMiddle AgedMultiple SclerosisPolymorphism, Single NucleotideChemokines, CC

Identifiers

PMID18602166
PMCPMC5301077
OpenAlexW2115460903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.