ArticleAtherosclerosis2009
Role of homocysteine in aortic calcification and osteogenic cell differentiation.
Article in Atherosclerosis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- The association of osteoporosis and cardiovascular disease risk score based on the Framingham and ACC/AHA risk prediction models: a cross-sectional analysis of Bushehr Elderly Health Program.Journal of diabetes and metabolic disorders · 2024Article
- CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification.JCI insight · 2024Article
- Serum Homocysteine and Vascular Calcification: Advances in Mechanisms, Related Diseases, and Nutrition.Korean journal of family medicine · 2022Article
- Associations of Serum and Red Blood Cell Folate With All-Cause and Cardiovascular Mortality Among Hypertensive Patients With Elevated Homocysteine.Frontiers in nutrition · 2022Article
- The Gasotransmitter Hydrogen Sulfide (HAntioxidants (Basel, Switzerland) · 2021Article
- Cut-off value of serum homocysteine in relation to increase of coronary artery calcification.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021Article
- Case Report: Two Novel Frameshift Mutations inFrontiers in genetics · 2021Article
- Review
- Association Between Homocysteine and Vascular Calcification Incidence, Prevalence, and Progression in the MESA Cohort.Journal of the American Heart Association · 2020Article
- Hyperhomocysteinemia induces vascular calcification by activating the transcription factor RUNX2 via Krüppel-like factor 4 up-regulation in mice.The Journal of biological chemistry · 2019Article
- Review
- Transcriptome Profiling in Systems Vascular Medicine.Frontiers in pharmacology · 2017Article
- Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- A review of the effect of diet on cardiovascular calcification.International journal of molecular sciences · 2015Review
- Recurrent white thrombi formation in hemodialysis tubing: a case report.BMC nephrology · 2015Article
- Risk factors in the progression of subclinical atherosclerosis in women with systemic lupus erythematosus.Arthritis care & research · 2014Article
- Severity of aortic calcification is positively associated with vertebral fracture in older men--a densitometry study in the STRAMBO cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Article
- Relationship between paraoxonase and homocysteine: crossroads of oxidative diseases.Archives of medical science : AMS · 2012Article
- Association between cardiovascular diseases and osteoporosis-reappraisal.BoneKEy reports · 2012Article
- Oxidized low-density lipoprotein and β-glycerophosphate synergistically induce endothelial progenitor cell ossification.Acta pharmacologica Sinica · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundThe role of homocysteine in atherosclerosis is unclear. We examined the relationship between plasma homocysteine and infrarenal aortic calcification, the presence of homocysteine in human atheroma and the influence of homocysteine on osteogenic differentiation in vitro. METHODS AND
resultsIn 194 patients with symptomatic peripheral artery disease or abdominal aortic aneurysm, fasting plasma total homocysteine was independently associated with the severity of infrarenal aortic calcification measured by Computer Tomography Angiography (odds ratio 1.91, 95% confidence interval 1.17-3.21 for calcification >or=median). Homocysteine was identified in all 60 atheroma biopsies from 16 patients undergoing endarterectomy, and concentrations were significantly greater in the calcified biopsies (p=0.003). In vitro studies demonstrated that 100 micromol/L homocysteine doubled the calcium deposition by mesenchymal stem cells during 16 days incubation in osteogenic medium (74+/-4 compared to 42+/-5 microg calcium/well without homocysteine, p<0.001). Homocysteine also stimulated monocytic THP1 cells to promote aortic smooth muscle cell calcification as evidenced by significant higher calcium deposition and alkaline phosphatase activity compared to incubation without homocysteine (p<or=0.05).
conclusionsHomocysteine plays an important role in vascular calcification via multiple mechanisms. The presence of homocysteine in atheroma and its ability to enhance osteogenic cell differentiation may partly explain the association of homocysteine with atherosclerotic events.
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Registered trials
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