Evidence map›Paper›PMID 18600578›Full record

ReviewCurrent opinion in investigational drugs (London, England : 2000)2008

Neuroimmune interactions and pain: focus on glial-modulating targets.

Edgar Alfonso Romero-Sandoval, Ryan J Horvath, Joyce A DeLeo

Abstract readReview
PubMed Full text at PMC
In one paragraph

Review in Current opinion in investigational drugs (London, England : 2000), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. The role of astrocytes in neuropathic pain.Frontiers in molecular neuroscience · 2022
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Edgar Alfonso Romero-SandovalDepartment of Anesthesiology, Dartmouth-Hitchcock Medical Center, HB 7125, One Medical Center Drive, Lebanon, NH 03756, USA. Edgar.A.Romero-Sandoval@dartmouth.edu
Ryan J Horvath
Joyce A DeLeo

Funding

Alternatives to Opioids for Chronic Pain: Part IVR01DA011276 · NIDA · DARTMOUTH COLLEGE · PI DE LEO, JOYCE A · 1997 to 2010
$3.1M
NIDA NIH HHS DA11276NIDA NIH HHS R01 DA011276
6 · The paper itself

Abstract

Chronic pain is the most difficult type of pain to treat. Previously, the development of analgesics has focused on neuronal targets; however, current analgesics are only modestly effective, have significant side effects and do not provide universal efficacy. New strategies are needed for the development of more effective analgesics. Glial cells have integral roles in CNS homeostasis, and chronic pain etiology and progression. In this review, the role of glia in neuropathic pain and opioid administration is described, as well as the potential superior efficacy and wider therapeutic indices provided by drugs that modulate specific glial function via novel targets.

Indexed as

AnalgesicsAnalgesics, OpioidAnimalsCannabinoidsHumansNeurogliaPainAnalgesicsAnalgesics, OpioidCannabinoids

Identifiers

PMID18600578
PMCPMC2696046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.