ArticleMolecular biology reports2009
Apolipoprotein E polymorphism in normal Han Chinese population: frequency and effect on lipid parameters.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Apolipoprotein E gene polymorphisms are associated with primary hyperuricemia in a Chinese population.PloS one · 2014Trial
- Association ofSaudi journal of biological sciences · 2023Article
- Mild cognitive impairment among rural-dwelling older adults in China: A community-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Genetic Effects of NDUFAF6 rs6982393 and APOE on Alzheimer's Disease in Chinese Rural Elderly: A Cross-Sectional Population-Based Study.Clinical interventions in aging · 2022Article
- APOE gene ɛ4 allele (388C-526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population.Journal of clinical laboratory analysis · 2021Article
- TOMM40 and APOE variants synergistically increase the risk of Alzheimer's disease in a Chinese population.Aging clinical and experimental research · 2021Article
- The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population.Lipids in health and disease · 2020Article
- Analysis of SLCO1B1 and APOE genetic polymorphisms in a large ethnic Hakka population in southern China.Journal of clinical laboratory analysis · 2018Article
- Polymorphism and plasma levels of apolipoprotein E and the risk of aneurysmal subarachnoid hemorrhage in a Chinese population: a case-control study.Lipids in health and disease · 2018Article
- Apolipoprotein E gene polymorphism and serum lipid profile in Saudi patients with psoriasis.Disease markers · 2014Article
- Aberrant apolipoprotein E expression and cognitive dysfunction in patients with poststroke depression.Genetic testing and molecular biomarkers · 2013Article
- The role of PRKCH gene variants in coronary artery disease in a Chinese population.Molecular biology reports · 2012Article
- Matrix metalloproteinase-9 functional promoter polymorphism 1562C>T increased risk of early-onset coronary artery disease.Molecular biology reports · 2012Article
- Apolipoprotein A5-1131T>C polymorphism, but not APOE genotypes, increases susceptibility for dyslipidemia in children and adolescents.Molecular biology reports · 2011Article
- Association between apolipoprotein ε4 allele, factor V Leiden, and plasma lipid and lipoprotein levels with sickle cell disease in Southern Iran.Molecular biology reports · 2011Article
- Variable frequencies of apolipoprotein E genotypes and its effect on serum lipids in the Guangxi Zhuang and Han children.International journal of molecular sciences · 2011Article
- Does the geographical gradient of ApoE4 allele exist in China? A systemic comparison among multiple Chinese populations.Molecular biology reports · 2011Article
- APOE polymorphism is associated with lipid profile, but not with arterial stiffness in the general population.Lipids in health and disease · 2010Article
- Analysis of apolipoprotein E genetic polymorphism in a large ethnic Hakka population in southern China.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apolipoprotein E (ApoE) genotypes were studied in order to determine the prevalence and effect on lipid parameters in normal Han Chinese population. Fragments of ApoE gene forth exon containing codon 112 and 158 polymorphic locus were amplified by PCR, and then digested with Cfo I endonuclease. Genotypes and alleles frequencies of 168 healthy Han Chinese were calculated. The frequency of genotypes epsilon3/3, epsilon3/4, and epsilon2/3 was found to be 75.00, 10.70, and 11.90%, respectively, and 0.60, 1.20, and 0.60% for epsilon2/2, epsilon2/4, and epsilon4/4. The effects of ApoE genotypes and alleles on lipid parameters were analyzed. The effects of ApoE alleles on TC, LDL-C, ApoB was: along a decreasing gradient epsilon4 > epsilon3 > epsilon2. The effect of epsilon4 allele was to increase serum levels of TC, LDL-C and ApoB, and epsilon2 allele had an effect opposite to that of epsilon4 allele. Results obtained in this study indicate that ApoE polymorphism is an independent genetic factor on individual serum levels of lipids and apolipoproteins.
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