ArticleChromosoma2008
Spatio-temporal dynamics of replication and transcription sites in the mammalian cell nucleus.
Article in Chromosoma, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Review
- Nanoscale Distribution of Nuclear Sites by Super-Resolved Image Cross-Correlation Spectroscopy.Biophysical journal · 2019Article
- Chromosome territories and the global regulation of the genome.Genes, chromosomes & cancer · 2019Review
- Insights into the Link between the Organization of DNA Replication and the Mutational Landscape.Genes · 2019Review
- Detection of RNA-DNA association by a proximity ligation-based method.Scientific reports · 2016Article
- Reorganization of the interchromosomal network during keratinocyte differentiation.Chromosoma · 2016Article
- Large-scale probabilistic 3D organization of human chromosome territories.Human molecular genetics · 2016Article
- Non-Random Patterns in the Distribution of NOR-Bearing Chromosome Territories in Human Fibroblasts: A Network Model of Interactions.Journal of cellular physiology · 2015Article
- Gene density and chromosome territory shape.Chromosoma · 2014Article
- Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome.Human molecular genetics · 2014Article
- Alterations in replication timing of cancer-related genes in malignant human breast cancer cells.Journal of cellular biochemistry · 2013Article
- Article
- 3D chromatin conformation correlates with replication timing and is conserved in resting cells.Nucleic acids research · 2012Article
- The radial nuclear positioning of genes correlates with features of megabase-sized chromatin domains.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression.Nucleic acids research · 2010Article
- The architecture of functional neighborhoods within the mammalian cell nucleus.Advances in enzyme regulation · 2010Review
- Modulatory effect of rRNA synthesis and ppUL83 nucleolar compartmentalization on human cytomegalovirus gene expression in vitro.Journal of cellular biochemistry · 2009Article
- Identification of a novel, widespread, and functionally important PCNA-binding motif.The Journal of cell biology · 2009Article
- Chromatin dynamics is correlated with replication timing.Chromosoma · 2009Article
- Organization of the amplified type I interferon gene cluster and associated chromosome regions in the interphase nucleus of human osteosarcoma cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
To study when and where active genes replicated in early S phase are transcribed, a series of pulse-chase experiments are performed to label replicating chromatin domains (RS) in early S phase and subsequently transcription sites (TS) after chase periods of 0 to 24 h. Surprisingly, transcription activity throughout these chase periods did not show significant colocalization with early RS chromatin domains. Application of novel image segmentation and proximity algorithms, however, revealed close proximity of TS with the labeled chromatin domains independent of chase time. In addition, RNA polymerase II was highly proximal and showed significant colocalization with both TS and the chromatin domains. Based on these findings, we propose that chromatin activated for transcription dynamically unfolds or "loops out" of early RS chromatin domains where it can interact with RNA polymerase II and other components of the transcriptional machinery. Our results further suggest that the early RS chromatin domains are transcribing genes throughout the cell cycle and that multiple chromatin domains are organized around the same transcription factory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.