ArticleCell death and differentiation2008
Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death.
Article in Cell death and differentiation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed, 120 citations in OpenAlex.
- Neonatal hyperoxia exposure causes cerebellar lesions and behavioral abnormalities in rats.Scientific reports · 2026Article
- Review
- Lipopolysaccharide Sensitizes Steroid-Induced Brain Injury in Neonatal Rat Pups.Mediators of inflammation · 2025Article
- Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents.Cells · 2024Review
- Identification of novel NRF2-dependent genes as regulators of lead and arsenic toxicity in neural progenitor cells.Journal of hazardous materials · 2024Article
- Cerebellar development after preterm birth.Frontiers in cell and developmental biology · 2022Review
- Single neonatal dexamethasone administration has long-lasting outcome on depressive-like behaviour, Bdnf, Nt-3, p75ngfr and sorting receptors (SorCS1-3) stress reactive expression.Scientific reports · 2021Article
- Argentic staining reveals changes in cerebellar tissue organisation by prenatal glucocorticoid administration in rats.Histology and histopathology · 2021Article
- Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events.Frontiers in systems neuroscience · 2021Review
- Commentary - Cerebellar underdevelopment in the very preterm infant: Important and underestimated source of cognitive deficits.Journal of neonatal-perinatal medicine · 2021Article
- Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum.Brain sciences · 2020Article
- Zika Virus Infection in the Developing Mouse Produces Dramatically Different Neuropathology Dependent on Viral Strain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Human Embryonic Stem Cell-Derived Neural Lineages asBioMed research international · 2019Article
- Preterm Birth and the Risk of Neurodevelopmental Disorders - Is There a Role for Epigenetic Dysregulation?Current genomics · 2018Review
- Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury.Cerebellum (London, England) · 2018Article
- 11β-HSD Types 1 and 2 in the Songbird Brain.Frontiers in endocrinology · 2018Article
- Nuclear receptors in neural stem/progenitor cell homeostasis.Cellular and molecular life sciences : CMLS · 2017Review
- Dexmedetomidine protects against glucocorticoid induced progenitor cell apoptosis in neonatal mouse cerebellum.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2017Article
- Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish.Scientific reports · 2017Article
- Antidepressant responsiveness in adulthood is permanently impaired after neonatal destruction of the neurogenic pool.Translational psychiatry · 2017Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
There has been a growing controversy regarding the continued use of glucocorticoid therapy to treat respiratory dysfunction associated with prematurity, as mounting clinical evidence has shown neonatal exposure produces permanent neuromotor and cognitive deficits. Here we report that, during a selective neonatal window of vulnerability, a single glucocorticoid injection in the mouse produces rapid and selective apoptotic cell death of the proliferating neural progenitor cells in the cerebellar external granule layer and permanent reductions in neuronal cell counts of their progeny, the cerebellar internal granule layer neurons. Our estimates suggest that this mouse window of vulnerability would correspond in the human to a period extending from approximately 20 weeks gestation to 6.5 weeks after birth. This death pathway is critically regulated by the proapoptotic Bcl-2 family member Puma and is independent of p53 expression. These rodent data indicate that there exists a previously unknown window of vulnerability during which a single glucocorticoid exposure at clinically relevant doses can produce neural progenitor cell apoptosis and permanent cerebellar pathology that may be responsible for some of the iatrogenically induced neurodevelopmental abnormalities seen in children exposed to this drug. This vulnerability may be related to the physiological role of glucocorticoids in regulating programmed cell death in the mammalian cerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.