ArticleBiophysical journal2008
Filamentous network mechanics and active contractility determine cell and tissue shape.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Actuation of Cell Layers in Three Dimensions.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Nucleo-cytoskeletal coupling controls intracellular deformation partitioning during cell stretching.Royal Society open science · 2025Article
- Dynamic mechanisms for membrane skeleton transitions.Journal of cell science · 2025Article
- Diffusion model predicts the geometry of actin cytoskeleton from cell morphology.PLoS computational biology · 2024Article
- Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cell cortex.Nature communications · 2024Article
- Dynamic mechanisms for membrane skeleton transitions.bioRxiv : the preprint server for biology · 2024Article
- The weakness of senescent dermal fibroblasts.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Force propagation between epithelial cells depends on active coupling and mechano-structural polarization.eLife · 2023Article
- SFAlab: image-based quantification of mechano-active ventral actin stress fibers in adherent cells.Frontiers in cell and developmental biology · 2023Article
- Curved Nanofiber Network Induces Cellular Bridge Formation to Promote Stem Cell Mechanotransduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Actin Stress Fibers Response and Adaptation under Stretch.International journal of molecular sciences · 2022Article
- Quantifying force transmission through fibroblasts: changes of traction forces under external shearing.European biophysics journal : EBJ · 2022Article
- Article
- Channeling Effect and Tissue Morphology in a Perfusion Bioreactor Imaged by X-Ray Microtomography.Tissue engineering and regenerative medicine · 2020Article
- Crosshatch nanofiber networks of tunable interfiber spacing induce plasticity in cell migration and cytoskeletal response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Extracellular Matrix Geometry and Initial Adhesive Position Determine Stress Fiber Network Organization during Cell Spreading.Cell reports · 2019Article
- Article
- Bimodal sensing of guidance cues in mechanically distinct microenvironments.Nature communications · 2018Article
- Post-Turing tissue pattern formation: Advent of mechanochemistry.PLoS computational biology · 2018Article
- Mechanosensitivity of Cancer Cells in Contact with Soft Substrates Using AFM.Biophysical journal · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For both cells and tissues, shape is closely correlated with function presumably via geometry-dependent distribution of tension. In this study, we identify common shape determinants spanning cell and tissue scales. For cells whose sites of adhesion are restricted to small adhesive islands on a micropatterned substrate, shape resembles a sequence of inward-curved circular arcs. The same shape is observed for fibroblast-populated collagen gels that are pinned to a flat substrate. Quantitative image analysis reveals that, in both cases, arc radii increase with the spanning distance between the pinning points. Although the Laplace law for interfaces under tension predicts circular arcs, it cannot explain the observed dependence on the spanning distance. Computer simulations and theoretical modeling demonstrate that filamentous network mechanics and contractility give rise to a modified Laplace law that quantitatively explains our experimental findings on both cell and tissue scales. Our model in conjunction with actomyosin inhibition experiments further suggests that cell shape is regulated by two different control modes related to motor contractility and structural changes in the actin cytoskeleton.
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