ArticleBiophysical journal2008
Effect of trehalose on a phospholipid membrane under mechanical stress.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Lipid remodeling enables adaptation to chronic hyperosmotic stress.The Journal of cell biology · 2026Article
- Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1).PLoS computational biology · 2024Article
- Extending the Martini 3 Coarse-Grained Force Field to Carbohydrates.Journal of chemical theory and computation · 2022Article
- Exogenous Indole-3-Acetic Acid Induced Ethanol Tolerance in Phylogenetically Diverse Saccharomycetales Yeasts.Microbes and environments · 2022Article
- Mechanistic differences in the effects of sucrose and sucralose on the phase stability of lysozyme solutions.Journal of molecular liquids · 2021Article
- Proteomics-Based Mechanistic Investigation ofFrontiers in microbiology · 2019Article
- Drought response transcriptomes are altered in poplar with reduced tonoplast sucrose transporter expression.Scientific reports · 2016Article
- Article
- Effect of the cosolutes trehalose and methanol on the equilibrium and phase-transition properties of glycerol-monopalmitate lipid bilayers investigated using molecular dynamics simulations.European biophysics journal : EBJ · 2014Article
- Localization of trehalose in partially hydrated DOPC bilayers: insights into cryoprotective mechanisms.Journal of the Royal Society, Interface · 2014Article
- Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli.Nature chemical biology · 2014Article
- Quantitative analysis of glycerol accumulation, glycolysis and growth under hyper osmotic stress.PLoS computational biology · 2013Article
- Trehalose-enhanced isolation of neuronal sub-types from adult mouse brain.BioTechniques · 2012Article
- Statistical thermodynamics of biomembranes.Cryobiology · 2010Article
- Synthetic trehalose glycolipids confer desiccation resistance to supported lipid monolayers.Langmuir : the ACS journal of surfaces and colloids · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Explicit solvent molecular dynamics simulations were used to investigate at atomic resolution the effect of trehalose on a hydrated phospholipid bilayer under mechanical stress (stretching forces imposed in the form of negative lateral pressure). Simulations were performed in the absence or presence of trehalose at 325 K, and with different values for negative lateral pressure. In the concentration regime (2 molal) and range of lateral pressures (1 to -250 bar) investigated, trehalose was found to interact directly with the membrane, partially replacing water molecules in the formation of hydrogen bonds with the lipid headgroups. Similar to previous findings in the context of thermal stress, the number, degree of bridging, and reaching depth of these hydrogen bonds increased with the magnitude of perturbation. However, at the concentration considered, trehalose was not sufficient to preserve the integrity of the membrane structure and to prevent its extreme elongation (and possible disruption) under the effect of stretching forces.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.