ArticleBiophysical journal2008
Small RNAs establish delays and temporal thresholds in gene expression.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- Chromosome segregation synchrony in S. pombe is noise limited and arises without positive feedback.The Journal of cell biology · 2026Article
- Chromosome segregation synchrony inbioRxiv : the preprint server for biology · 2026Article
- How memory and adaptation cost shape cell phenotypic dynamics in response to fluctuating environments.bioRxiv : the preprint server for biology · 2025Article
- Suppression of HIV-1 transcription and latency reversal via ectopic expression of the viral antisense transcript AST.Science advances · 2025Article
- Temporally controlled multistep division of DNA droplets for dynamic artificial cells.Nature communications · 2024Article
- Reinventing gene expression connectivity through regulatory and spatial structural empowerment via principal node aggregation graph neural network.Nucleic acids research · 2024Article
- Origin and functional role of antisense transcription in endogenous and exogenous retroviruses.Retrovirology · 2023Review
- The effect of microRNA on protein variability and gene expression fidelity.Biophysical journal · 2023Article
- Review
- Inverse regulation of light harvesting and photoprotection is mediated by a 3'-end-derived sRNA in cyanobacteria.The Plant cell · 2021Article
- Regulation and Functional Complexity of the Chlorophyll-Binding Protein IsiA.Frontiers in microbiology · 2021Review
- Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities.Cell reports · 2019Article
- Function of the IsiA pigment-protein complex in vivo.Photosynthesis research · 2019Article
- DICER1 regulates antibacterial function of epididymis by modulating transcription of β-defensins.Journal of molecular cell biology · 2019Article
- A unique ferredoxin acts as a player in the low-iron response of photosynthetic organisms.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Synthetic negative feedback circuits using engineered small RNAs.Nucleic acids research · 2018Article
- Widespread Antisense Transcription in Prokaryotes.Microbiology spectrum · 2018Review
- Stochastic Modeling of Gene Regulation by Noncoding Small RNAs in the Strong Interaction Limit.Biophysical journal · 2018Article
- Regulatory sRNAs in Cyanobacteria.Frontiers in microbiology · 2018Review
- Modeling sRNA-Regulated Plasmid Maintenance.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noncoding RNAs are crucial regulators of gene expression in prokaryotes and eukaryotes, but how they affect the dynamics of transcriptional networks remains poorly understood. We analyzed the temporal characteristics of the cyanobacterial iron stress response by mathematical modeling and quantitative experimental analyses and focused on the role of a recently discovered small noncoding RNA, IsrR. We found that IsrR is responsible for a pronounced delay in the accumulation of isiA mRNA encoding the late-phase stress protein, IsiA, and that it ensures a rapid decline in isiA levels once external stress triggers are removed. These kinetic properties allow the system to selectively respond to sustained (as opposed to transient) stimuli and thus establish a temporal threshold, which prevents energetically costly IsiA accumulation under short-term stress conditions. Biological information is frequently encoded in the quantitative aspects of intracellular signals (e.g., amplitude and duration). Our simulations reveal that competitive inhibition and regulated degradation allow intracellular regulatory networks to efficiently discriminate between transient and sustained inputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.