ArticleThe Plant cell2008
Badh2, encoding betaine aldehyde dehydrogenase, inhibits the biosynthesis of 2-acetyl-1-pyrroline, a major component in rice fragrance.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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Who cites it
125 citing papers in PubMed, 362 citations in OpenAlex.
- Development of fragrant broomcorn millet (Panicum miliaceum L.) via CRISPR/Cas12i.3-mediated genome editing.Journal of integrative plant biology · 2026Article
- Negative Regulators of Rice Agronomic Traits: Functional Insights and Applications in Genome Editing-Based Breeding.Plant biotechnology journal · 2026Review
- SorghumHub: featuring the next phase for the KBCommons web portal with new molecular biology features.BMC genomics · 2026Article
- Nano-Molybdenum Disulfide Enhances Antioxidant Defense and Aroma Formation in Fragrant Rice Under Cadmium Stress via Modulation of 2-Acetyl-1-Pyrroline Biosynthesis.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Multiplex Gene Editing and Effect Analysis of Yield, Fragrance, and Blast Resistance Genes in Rice.Genes · 2026Article
- Improvement in the quality of the water-saving and drought-resistant rice 'Huhan 1516' via molecular markers.Molecular breeding : new strategies in plant improvement · 2025Article
- Study on Differences in 2-AP Synthesis and Metabolism Among Fragrant Rice Varieties.International journal of molecular sciences · 2025Article
- A mutation in CmoBADH results in the production of 2-acetyl-1-pyrroline, conferring a 'taro-like' aroma in Cucurbita moschata.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Development and Application of an SNP Marker for High-Throughput Detection and Utilization of theGenes · 2025Article
- Engineering Adenine Deaminase TadA for Precise and PAM-Flexible Point Mutagenesis and Gradient-Tuning Endogenous Protein Design.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- GmMYB93 increases aroma formation in soybean by inhibiting the expression of a betaine aldehyde dehydrogenase gene.aBIOTECH · 2025Article
- Effects of variety degeneration on yield formation, quality traits and 2-acetyl-1-pyrroline biosynthesis in high-quality Japonica rice.Rice (New York, N.Y.) · 2025Article
- Alternative splicing-mediated regulation of a novel allele of Badh2 drives moderate accumulation of 2-AP in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Breeding a novel cauliflower with exceptional fragrance.Molecular horticulture · 2025Article
- Creation of fragrant peanut using CRISPR/Cas9.Journal of integrative plant biology · 2025Article
- Unlocking genetic hotspots: GWAS reveals key nitrogen responsive genomic regions and key genes for root and yield traits in indica rice.Molecular genetics and genomics : MGG · 2025Article
- Engineering stress resistance: advances in glycine betaine production for sustainable agriculture.Crop health · 2025Review
- Divergent genetic architecture of cold stress tolerance inFrontiers in plant science · 2025Article
- Improving the Aroma of Millets by Targeting theCurrent genomics · 2025Review
65 more citing papers are in PubMed but not listed here.
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9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In rice (Oryza sativa), the presence of a dominant Badh2 allele encoding betaine aldehyde dehydrogenase (BADH2) inhibits the synthesis of 2-acetyl-1-pyrroline (2AP), a potent flavor component in rice fragrance. By contrast, its two recessive alleles, badh2-E2 and badh2-E7, induce 2AP formation. Badh2 was found to be transcribed in all tissues tested except for roots, and the transcript was detected at higher abundance in young, healthy leaves than in other tissues. Multiple Badh2 transcript lengths were detected, and the complete, full-length Badh2 transcript was much less abundant than partial Badh2 transcripts. 2AP levels were significantly reduced in cauliflower mosaic virus 35S-driven transgenic lines expressing the complete, but not the partial, Badh2 coding sequences. In accordance, the intact, full-length BADH2 protein (503 residues) appeared exclusively in nonfragrant transgenic lines and rice varieties. These results indicate that the full-length BADH2 protein encoded by Badh2 renders rice nonfragrant by inhibiting 2AP biosynthesis. The BADH2 enzyme was predicted to contain three domains: NAD binding, substrate binding, and oligomerization domains. BADH2 was distributed throughout the cytoplasm, where it is predicted to catalyze the oxidization of betaine aldehyde, 4-aminobutyraldehyde (AB-ald), and 3-aminopropionaldehyde. The presence of null badh2 alleles resulted in AB-ald accumulation and enhanced 2AP biosynthesis. In summary, these data support the hypothesis that BADH2 inhibits 2AP biosynthesis by exhausting AB-ald, a presumed 2AP precursor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.