Evidence map›Paper›PMID 18599130›Full record

ReviewBehavioural brain research2008

Neuroimaging, genetics and the treatment of nicotine addiction.

Riju Ray, James Loughead, Ze Wang, John Detre, Edward Yang, Ruben Gur, Caryn Lerman

Open access · greenAbstract readReview
In one paragraph

Review in Behavioural brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Are adolescents with ADHD interested in genetic testing for nicotine addiction susceptibility?International journal of environmental research and public health · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Riju RayTrandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
James Loughead
Ze Wang
John Detre
Edward Yang
Ruben Gur
Caryn Lerman
University of Pennsylvania · US

Funding

Theta and Gamma Oscillations in Cortical MicrocircuitsP50MH064045 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2001 to 2010
$21.6M
TRANSDISCIPLINARY TOBACCO USE RESEARCH CENTERSP50CA084718 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LERMAN, CARYN · 1999 to 2008
$17.8M
WORKSHOP ON ADVANCES IN MUSCULOSKELETAL MRIP41RR002305 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI SONG, HEE KWON · 1985 to 2011
$14.7M
statistics coreP30NS045839 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 2003 to 2017
$10.1M
The Neurobiology of Affective Dysfunction in SchizophreniaR01MH060722 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RUBEN C. · 2001 to 2010
$4.8M
Perfusion MRI for Multi-site Studies of Brain FunctionR01MH080729 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ALSOP, DAVID CHARLES, DETRE, JOHN A · 2007 to 2017
$3.8M
Pharmacogenetic Investigation of Naltrexone (RMI)R01DA017555 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI LERMAN, CARYN · 2003 to 2007
$2.2M
Mentoring and research in translational neuroimagingK24NS058386 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 2007 to 2011
$597k
SVM based group data analysis for drug abuse disorder ASL perfusion studyR03DA023496 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WANG, ZE · 2007 to 2007
$236k
NCI NIH HHS P50 CA084718NCI NIH HHS P50 CA/DA84718NCRR NIH HHS P41 RR002305NCRR NIH HHS RR002305NIDA NIH HHS R01 DA017555NIDA NIH HHS R03 DA023496NIMH NIH HHS MH080729NIMH NIH HHS MH60722NIMH NIH HHS P50 MH064045NIMH NIH HHS P50 MH64045NIMH NIH HHS R01 MH060722NIMH NIH HHS R01 MH080729NINDS NIH HHS K24 NS058386NINDS NIH HHS NS045839NINDS NIH HHS NS058386NINDS NIH HHS P30 NS045839
6 · The paper itself

Abstract

Advances in neuroimaging and genomics provide an unprecedented opportunity to accelerate medication development for nicotine dependence and other addictions. Neuroimaging studies have begun to elucidate the functional neuroanatomy and neurochemistry underlying effects of nicotine and nicotine abstinence. In parallel, genetic studies, including both candidate gene and genome-wide association approaches, are identifying key neurobiological targets and pathways important in addiction to nicotine. To date, only a few neuroimaging studies have explored effects of nicotine or abstinence on brain activity as a function of genotype. Most analyses of genotype are retrospective, resulting in small sample sizes for testing effects of the minor alleles for candidate genes. The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment.

Indexed as

Behavior, AddictiveDiagnostic ImagingGenetic Predisposition to DiseaseGenomicsGenotypeHumansPositron-Emission TomographySmokingSmoking PreventionTobacco Use Disorder

Identifiers

PMID18599130
PMCPMC2600518
OpenAlexW1981910506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.