Evidence map›Paper›PMID 18598988›Full record

ArticleHeart failure clinics2008

Computational modeling for bedside application.

Roy C P Kerckhoffs, Sanjiv M Narayan, Jeffrey H Omens, Lawrence J Mulligan, Andrew D McCulloch

Abstract read
In one paragraph

Article in Heart failure clinics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Current progress in patient-specific modeling.Briefings in bioinformatics · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roy C P KerckhoffsDepartment of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093-0412, USA. rkerckhoffs@ucsd.edu
Sanjiv M Narayan
Jeffrey H Omens
Lawrence J Mulligan
Andrew D McCulloch

Funding

VISUALIZATION TOOLS FOR AUTOMATED MOLECULAR MICROSCOPYP41RR008605 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAPADOPOULOS, PHILIP · 1994 to 2011
$28.1M
The Dynamics of Human Atrial FibrillationR01HL083359 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sanjiv M Narayan · 2008 to 2026
$7.9M
TRANSMURAL DEFORMATIONR01HL032583 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OMENS, JEFFREY H. · 1985 to 2008
$2.8M
Multi-Scale Modeling of the Failing Heart for Cardiac Rysynchronization TherapyR01HL096544 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D. · 2009 to 2013
$1.8M
INFRASTRUCTURE OF BIOENGINEERING DEVELOPMENTC06RR017588 · NCRR · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI GOUGH, DAVID A · 2002 to 2002
$696k
NCRR NIH HHS C06 RR017588NCRR NIH HHS C06 RR-017588-01NCRR NIH HHS P41 RR008605NCRR NIH HHS P41 RR08605NHLBI NIH HHS HL32583NHLBI NIH HHS HL83359NHLBI NIH HHS R01 HL032583NHLBI NIH HHS R01 HL083359NHLBI NIH HHS R01 HL096544
6 · The paper itself

Abstract

Advances in computer power, novel diagnostic and therapeutic medical technologies, and an increasing knowledge of pathophysiology from gene to organ systems make it increasingly feasible to apply multiscale patient-specific modeling based on proven disease mechanisms. Such models may guide and predict the response to therapy in many areas of medicine. This is an exciting and relatively new approach, for which efficient methods and computational tools are of the utmost importance. Investigators have designed patient-specific models in almost all areas of human physiology. Not only will these models be useful in clinical settings to predict and optimize the outcome from surgery and non-interventional therapy, but they will also provide pathophysiologic insights from the cellular level to the organ system level. Models, therefore, will provide insight as to why specific interventions succeed or fail.

Indexed as

Computer SimulationHeart DiseasesModels, TheoreticalArtificial IntelligenceClinical ProtocolsHumansSoftware

Identifiers

PMID18598988
PMCPMC2518746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.