Evidence map›Paper›PMID 18598910›Full record

ReviewDrug discovery today2008

Biosynthesis, degradation and pharmacological importance of the fatty acid amides.

Emma K Farrell, David J Merkler

Abstract readReview
In one paragraph

Review in Drug discovery today, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A human gutScience (New York, N.Y.) · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Investigating the Underlying Mechanisms ofMolecules (Basel, Switzerland) · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. International journal of molecular sciences · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Emma K FarrellDepartment of Chemistry, University of South Florida, Tampa, FL 33620, USA.
David J Merkler

Funding

Enzymatic Cleavage of the C-N Bond in GlycineR15GM073659 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI MERKLER, DAVID J · 2005 to 2005
$218k
BIOSYNTHESIS OF OLEAMIDE AND OTHER FATTY ACID AMIDESR15GM059050 · NIGMS · UNIVERSITY OF SOUTH FLORIDA · PI MERKLER, DAVID J · 1999 to 1999
–
NIGMS NIH HHS R15 GM059050NIGMS NIH HHS R15-GM059050NIGMS NIH HHS R15 GM073659NIGMS NIH HHS R15-GM073659
6 · The paper itself

Abstract

The identification of two biologically active fatty acid amides, N-arachidonoylethanolamine (anandamide) and oleamide, has generated a great deal of excitement and stimulated considerable research. However, anandamide and oleamide are merely the best-known and best-understood members of a much larger family of biologically occurring fatty acid amides. In this review, we will outline which fatty acid amides have been isolated from mammalian sources, detail what is known about how these molecules are made and degraded in vivo, and highlight their potential for the development of novel therapeutics.

Indexed as

AmidesAmino Acids, AromaticAnimalsArachidonic AcidsDopamineEndocannabinoidsFatty AcidsHumansOleic AcidsPolyunsaturated AlkamidesAmidesAmino Acids, AromaticanandamideArachidonic AcidsDopamineEndocannabinoidsFatty AcidsOleic AcidsoleylamidePolyunsaturated Alkamides

Identifiers

PMID18598910
PMCPMC2667908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.