ReviewVaccine2008
Vaccine immunogenetics: bedside to bench to population.
Review in Vaccine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04430972 (Is Pre-operative Impaired imMune rEsponsiveness Associated With Adverse Outcome Following Aortic Valve Replacement SURgEry), which is not on this map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is Pre-operative Impaired imMune rEsponsiveness Associated With Adverse Outcome Following Aortic Valve Replacement SURgEry (MEASURE)
Who cites it
44 citing papers in PubMed, 69 citations in OpenAlex.
- A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.Vaccine · 2012Trial
- The role of HLA-DR-DQ haplotypes in variable antibody responses to anthrax vaccine adsorbed.Genes and immunity · 2011Trial
- Sex, Age, and Previous Herpes Zoster Infection Role on Adverse Events Following Immunization with Adjuvanted Recombinant Vaccine.Pathogens (Basel, Switzerland) · 2025Observational
- Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations.Frontiers in immunology · 2023Review
- A Clinical Trial of Entolimod a TLR-5 Adjuvant for Vaccines Using Diphtheria or Tetanus as Carrier Proteins.Vaccines · 2022Article
- Will Host Genetics Affect the Response to SARS-CoV-2 Vaccines? Historical Precedents.Frontiers in medicine · 2022Review
- Associations between Allelic Variants of the Human IgH 3' Regulatory Region 1 and the Immune Response to BNT162b2 mRNA Vaccine.Vaccines · 2021Article
- Differences in epitope-specific antibodies to pertussis toxin after infection and acellular vaccinations.Clinical & translational immunology · 2020Article
- The role of systems biology approaches in determining molecular signatures for the development of more effective vaccines.Expert review of vaccines · 2019Review
- Genetic regulation of antibody responsiveness to immunization in substrains of BALB/c mice.Immunology and cell biology · 2019Article
- OMIC Technologies and Vaccine Development: From the Identification of Vulnerable Individuals to the Formulation of Invulnerable Vaccines.Journal of immunology research · 2019Review
- Personalized vaccinology: A review.Vaccine · 2018Review
- Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children.Diabetologia · 2018Article
- Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults.Immunogenetics · 2016Article
- Review
- The role of Toll-like receptor 4 polymorphisms in vaccine immune response.The pharmacogenomics journal · 2016Review
- Reduced Human Leukocyte Antigen (HLA) Protection in Gulf War Illness (GWI).EBioMedicine · 2016Article
- Utilizing population variation, vaccination, and systems biology to study human immunology.Trends in immunology · 2015Review
- Searching for the human genetic factors standing in the way of universally effective vaccines.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- The genetic regulation of infant immune responses to vaccination.Frontiers in immunology · 2015Review
Corrections and comments
- Commented on by
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The immunogenetic basis for variations in immune response to vaccines in humans remains largely unknown. Many factors can contribute to the heterogeneity of vaccine-induced immune responses, including polymorphisms of immune response genes. It is important to identify those genes involved directly or indirectly in the generation of the immune response to vaccines. Our previous work with measles reveals the impact of immune response gene polymorphisms on measles vaccine-induced humoral and cellular immune responses. We demonstrate associations between genetic variations (single nucleotide polymorphisms, SNPs) in HLA class I and class II genes, cytokine, cell surface receptor, and toll-like receptor genes and variations in immune responses to measles vaccine. Such information may provide further understanding of genetic restrictions that influence the generation of protective immune responses to vaccines, and eventually the development of new vaccines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.