ArticleGastroenterology2008
Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB.
Article in Gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome.Science advances · 2024Article
- UBE2W Improves the Experimental Colitis by Inhibiting the NF-κB Signaling Pathway.Digestive diseases and sciences · 2022Article
- Article
- Systems biology approach highlights mechanistic differences between Crohn's disease and ulcerative colitis.Scientific reports · 2021Article
- Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.Nature communications · 2021Article
- Pharmacological activation of epidermal growth factor receptor signaling inhibits colitis-associated cancer in mice.Scientific reports · 2018Article
- Article
- A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation.Scientific reports · 2016Article
- Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model.PloS one · 2016Article
- LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis.Cell death and differentiation · 2015Article
- Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis.Biochimica et biophysica acta · 2015Article
- Article
- Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases.BMC immunology · 2012Article
- ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology.World journal of gastrointestinal pathophysiology · 2012Article
- Tumor necrosis factor receptor 1 functions as a tumor suppressor.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction.Inflammatory bowel diseases · 2011Article
- Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica.Mucosal immunology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
BACKGROUND &
aimsRaf-1 kinase is a key regulator of a number of cellular processes, which promote the maintenance of a healthy colon epithelium. This study addresses the role of Raf in epithelial cell survival in response to dextran sulfate sodium (DSS)-induced injury and inflammation.
methodsInducible intestinal epithelium-specific Raf knockout mice were generated and subjected to acute colitis followed by a short recovery period. Colon sections were analyzed by in situ oligo ligation or immunostaining for Ki67, phospho-extracellular signal regulated kinase, and nuclear factor-kappaB p65. Western blot analysis and terminal deoxynucleotidyl transferase nick-end labeling assays were performed on Raf small interfering RNA-transfected young adult mouse colon cells following DSS treatment.
resultsWe report that Raf protects against epithelial injury and inflammation and promotes recovery from acute DSS-induced colitis by both MAPK/ERK kinase (MEK)-dependent and -independent pathways. Furthermore, we demonstrate that Raf induces novel cell survival responses through activating nuclear factor-kappaB in a MEK-independent manner.
conclusionsThese novel findings indicate a protective role for Raf in colon epithelium following ulcerative damage through inhibiting cell apoptosis and promoting proliferation with important implications for responses such as inflammation-associated carcinogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.