ArticleBMC medical genetics2008
Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia.
Article in BMC medical genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data.American journal of obstetrics and gynecology · 2012Pooled it
- Preeclampsia and eclampsia: the conceptual evolution of a syndrome.American journal of obstetrics and gynecology · 2022Review
- Joint Associations of Maternal-Fetal APOL1 Genotypes and Maternal Country of Origin With Preeclampsia Risk.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
- A Multi-Marker Test for Analyzing Paired Genetic Data in Transplantation.Frontiers in genetics · 2021Review
- Joint testing of donor and recipient genetic matching scores and recipient genotype has robust power for finding genes associated with transplant outcomes.Genetic epidemiology · 2020Article
- Review
- Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls.Pregnancy hypertension · 2016Article
- Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes.Evolution, medicine, and public health · 2014Review
- Pre-eclampsia part 1: current understanding of its pathophysiology.Nature reviews. Nephrology · 2014Review
- Entropy-based selection for maternal-fetal genotype incompatibility with application to preterm prelabor rupture of membranes.BMC genetics · 2014Article
- The contribution of genetic and environmental factors to the duration of pregnancy.American journal of obstetrics and gynecology · 2014Review
- Deleterious impact of feto-maternal MHC compatibility on the success of pregnancy in a macaque model.Immunogenetics · 2014Article
- A NovelMolecular genetics & genomic medicine · 2013Article
- Structure of tumor necrosis factor-alpha haploblocks in European populations.Immunogenetics · 2013Article
- Fetal ERAP2 variation is associated with preeclampsia in African Americans in a case-control study.BMC medical genetics · 2011Article
- Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.PloS one · 2011Article
- Detection of intergenerational genetic effects with application to HLA-B matching as a risk factor for schizophrenia.Human heredity · 2011Article
- Investigation of maternal effects, maternal-fetal interactions and parent-of-origin effects (imprinting), using mothers and their offspring.Genetic epidemiology · 2011Article
Corrections and comments
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7 authors.
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Abstract
backgroundIn utero interactions between incompatible maternal and fetal genotypes are a potential mechanism for the onset or progression of pregnancy related diseases such as pre-eclampsia (PE). However, the optimal analytical approach and study design for evaluating incompatible maternal/offspring genotype combinations is unclear.
methodsUsing simulation, we estimated the type I error and power of incompatible maternal/offspring genotype models for two analytical approaches: logistic regression used with case-control mother/offspring pairs and the log-linear regression used with case-parent triads. We evaluated a real dataset consisting of maternal/offspring pairs with and without PE for incompatibility effects using the optimal analysis based on the results of the simulation study.
resultsWe identified a single coding scheme for the incompatibility effect that was equally or more powerful than all of the alternative analysis models evaluated, regardless of the true underlying model for the incompatibility effect. In addition, the log-linear regression was more powerful than the logistic regression when the heritability was low, and more robust to adjustment for maternal or fetal effects. For the PE data, this analysis revealed three genes, lymphotoxin alpha (LTA), von Willebrand factor (VWF), and alpha 2 chain of type IV collagen (COL4A2) with possible incompatibility effects.
conclusionThe incompatibility model should be evaluated for complications of pregnancy, such as PE, where the genotypes of two individuals may contribute to the presence of disease.
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