ArticleBMC geriatrics2008
Quality of anticoagulation and use of warfarin-interacting medications in long-term care: a chart review.
Article in BMC geriatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00990158 (A Multicentre Study of Low Dose Oral Vitamin K for INR Control in Patients Receiving Warfarin), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicentre Study of Low Dose Oral Vitamin K for INR Control in Patients Receiving Warfarin
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Use of warfarin in long-term care: a systematic review.BMC geriatrics · 2012Pooled it
- Prospective alpha allocation in the Clarification of Optimal Anticoagulation through Genetics (COAG) trial.Clinical trials (London, England) · 2010Trial
- Warfarin and Polypharmacy Challenges in Sudan: Drug Interactions in Patient Cohort.Integrated pharmacy research & practice · 2024Article
- Pharmacological treatments and medication-related problems in nursing homes in Catalonia: a multidisciplinary approach.Frontiers in pharmacology · 2024Article
- Comparison of potential pharmacokinetic drug interactions in patients with atrial fibrillation and changing from warfarin to non-vitamin K oral anticoagulant therapy.Journal of thrombosis and thrombolysis · 2021Article
- Evaluation of Warfarin Anticoagulation at University of Gondar Comprehensive Specialized Hospital, North-West Ethiopia.Journal of blood medicine · 2021Article
- Management of Outpatient Warfarin Therapy amid COVID-19 Pandemic: A Practical Guide.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2020Review
- Pharmacogenetics of warfarin dosing in patients of African and European ancestry.Pharmacogenomics · 2018Review
- Characteristics of patients with thromboembolic disorders on warfarin therapy in resource limited settings.BMC health services research · 2018Article
- Long-Term Statin Administration Does Not Affect Warfarin Time in Therapeutic Range in Australia or Singapore.Journal of clinical medicine · 2018Article
- Validation of knowledge and adherence assessment tools among patients on warfarin therapy in a Saudi hospital anticoagulant clinic.International journal of clinical pharmacy · 2018Article
- Quality of anticoagulation management with warfarin among outpatients in a tertiary hospital in Addis Ababa, Ethiopia: a retrospective cross-sectional study.BMC health services research · 2017Article
- Advantages of a Warfarin Protocol for Long-term Care Pharmacists: a Retrospective Cohort Study.Canadian geriatrics journal : CGJ · 2016Article
- Nurses' self-reported time estimation of anticoagulation therapy: a survey of warfarin management in long-term care.BMC nursing · 2015Article
- Drug-drug interactions and risk of bleeding among inpatients on warfarin therapy: a prospective observational study.Thrombosis journal · 2014Article
- Use of vitamin K antagonist therapy in geriatrics: a French national survey from the French Society of Geriatrics and Gerontology (SFGG).Drugs & aging · 2013Article
- Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more.Pharmacy practice · 2012Article
- The quality of warfarin prescribing and monitoring in Veterans Affairs nursing homes.Journal of the American Geriatrics Society · 2010Article
- A team-based approach to warfarin management in long term care: a feasibility study of the MEDeINR electronic decision support system.BMC geriatrics · 2010Article
- Point-of-Care International Normalized Ratio (INR) Monitoring Devices for Patients on Long-term Oral Anticoagulation Therapy: An Evidence-Based Analysis.Ontario health technology assessment series · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMaintenance of therapeutic International Normalized Ratio (INR) in the community is generally poor. The supervised environment in long-term care facilities may represent a more ideal setting for warfarin therapy since laboratory monitoring, compliance, dose adjustment, and interacting medications can all be monitored and controlled. The objectives of this study were to determine how effectively warfarin was administered to a cohort of residents in long-term care facilities, to identify the proportion of residents prescribed warfarin-interacting drugs and to ascertain factors associated with poor INR control.
methodsA chart review of 105 residents receiving warfarin therapy in five long-term care facilities in Hamilton, Ontario was performed. Data were collected on INR levels, warfarin prescribing and monitoring practices, and use of interacting medications.
resultsOver a 12 month period (28,555 resident-days, 78.2 resident years) 3065 INR values were available. Residents were within, below and above the therapeutic range 54%, 35% and 11% of the time, respectively. Seventy-nine percent of residents were prescribed at least one warfarin-interacting medication during the period in review. Residents receiving interacting medications spent less time in the therapeutic range (53.0% vs. 58.2%, OR = 0.93, 95% confidence interval 0.88 to 0.97, P = 0.002). Adequacy of anticoagulation varied significantly between physicians (time in therapeutic range 45.9 to 63.9%).
conclusionIn this group of long-term care residents, warfarin control was suboptimal. Both prescriber and co-prescription of interacting medications were associated with poorer INR control. Future studies should seek strategies to improve prescriber skill and decrease use of interacting medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.