ArticleThe European journal of neuroscience2008
Impaired GABAergic transmission disrupts normal homeostatic plasticity in rat cortical networks.
Article in The European journal of neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- The aging motor system as a model for plastic changes of GABA-mediated intracortical inhibition and their behavioral relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- The effect of repetitive transcranial magnetic stimulation on gamma oscillatory activity in schizophrenia.PloS one · 2011Trial
- Prelimbic cortex layer 5 GABAergic neurons mediate chronic pain and memory impairment by regulating excitatory/inhibitory imbalance.The journal of headache and pain · 2026Article
- Conditional learning increases inhibition of layer 4 excitatory neurons by somatostatin- and parvalbumin-expressing interneurons in the barrel cortex.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- The effects of amyloidosis and aging on glutamatergic and GABAergic synapses, and interneurons in the barrel cortex and non-neocortical brain regions.Frontiers in neuroanatomy · 2025Article
- Developmental hearing loss-induced perceptual deficits are rescued by genetic restoration of cortical inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer's disease.Molecular psychiatry · 2023Review
- Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABAbioRxiv : the preprint server for biology · 2023Article
- Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults.Human brain mapping · 2020Article
- A multiscale analysis in CD38FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Dp71-Dystrophin Deficiency Alters Prefrontal Cortex Excitation-Inhibition Balance and Executive Functions.Molecular neurobiology · 2019Article
- Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation/Inhibition Balance in the Medial Prefrontal Cortex.Biological psychiatry · 2018Article
- PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders.Frontiers in neural circuits · 2018Review
- D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period.PloS one · 2016Article
- Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex.Pflugers Archiv : European journal of physiology · 2015Article
- Neuroplastic effects of transcranial near-infrared stimulation (tNIRS) on the motor cortex.Frontiers in behavioral neuroscience · 2015Article
- Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging.Neurobiology of aging · 2012Article
- Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.Molecular psychiatry · 2012Article
- p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.The Journal of biological chemistry · 2011Article
- Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the cortex, homeostatic plasticity appears to be a key process for maintaining neuronal network activity in a functional range. This phenomenon depends on close interactions between excitatory and inhibitory circuits. We previously showed that application of a high frequency of stimulation (HFS) protocol in layer 2/3 induces parallel potentiation of excitatory and inhibitory inputs on layer 5 pyramidal neurons, leading to an unchanged excitation/inhibition (E/I) balance. These coordinated long-term potentiations of excitation and inhibition correspond to homeostatic plasticity of the neuronal networks. We showed here, on the rat visual cortex, that blockade (with gabazine) or overactivation (with 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) of GABA(A) receptors enhanced the E/I balance and prevented the potentiation of excitatory and inhibitory inputs after an HFS protocol. These impairements of the GABAergic transmission led to a long-term depression-like effect after an HFS protocol. We also observed that the blockade of inhibition reduced excitation (by 60%), and conversely, the blockade of excitation decreased inhibition (by 90%). These results support the idea that inhibitory interneurons are critical for recurrent interactions underlying homeostatic plasticity in cortical networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.