Evidence map›Paper›PMID 18598138›Full record

ReviewAnnual review of nutrition2008

Dietary manipulation of histone structure and function.

Barbara Delage, Roderick H Dashwood

Abstract readReview
In one paragraph

Review in Annual review of nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 151 citations in OpenAlex.

  1. Review
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  13. Reviewing cancer's biology: an eclectic approach.Journal of the Egyptian National Cancer Institute · 2021
    Review
  14. Observational
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors.Current topics in medicinal chemistry · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Barbara DelageLinus Pauling Institute, Oregon State University, Corvallis, Oregon 97331-6512, USA.
Roderick H Dashwood
Oregon State University · US

Funding

Transplacental Chemoprevention of Lung Tumors and LymphomasP01CA090890 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DASHWOOD, RODERICK H · 2003 to 2014
$14.2M
Dietary HDAC Inhibitors in Colon Cancer PreventionR01CA122959 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI DASHWOOD, RODERICK H · 2008 to 2023
$4.3M
Modulation of Colon Carcinogenesis by ChlorophyllinR01CA065525 · NCI · OREGON STATE UNIVERSITY · PI DASHWOOD, RODERICK H · 2004 to 2008
$1.5M
MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLINR29CA065525 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI DASHWOOD, RODERICK H · 1996 to 2000
$99k
NCI NIH HHS CA122959NCI NIH HHS CA65525NCI NIH HHS CA90890NCI NIH HHS P01 CA090890NCI NIH HHS R01 CA065525NCI NIH HHS R01 CA122959NCI NIH HHS R29 CA065525
6 · The paper itself

Abstract

Post-translational modifications of histones are the subject of intensive investigations with the aim of decoding how they regulate, alone or in combination, chromatin structure, genomic stability, and gene expression. Major epigenetic programming events take place during gametogenesis and fetal development and are thought to have long-lasting consequences on adult health. Epidemiological and experimental studies have pointed toward maternal nutrition as a major player during prenatal development in influencing disease susceptibility later in life. Although the mechanisms underlying such observations are not well elucidated, epigenetic alterations of histones by particular maternal diets might be of central importance. Moreover, as much as dietary sources can influence epigenetic programming during pregnancy, they have started to be implicated in cancer chemoprevention, via the targeting of reversible epigenetic deregulations at the level of the histones.

Indexed as

Epigenesis, GeneticGene Expression Regulation, DevelopmentalAnimalsDNA MethylationFemaleFetal Nutrition DisordersGene Expression RegulationGene SilencingHistonesHumansMaleMaternal Nutritional Physiological PhenomenaPregnancyPrenatal Exposure Delayed EffectsPrenatal Nutritional Physiological PhenomenaHistones

Identifiers

PMID18598138
PMCPMC2737739
OpenAlexW2145301532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.