ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2008
A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease.Scientific reports · 2016Article
- Sex and the single nucleotide polymorphism: exploring the genetic causes of skeletal sex differences.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Gene-based multiple trait analysis for exome sequencing data.BMC proceedings · 2011Article
- Bivariate association analysis in selected samples: application to a GWAS of two bone mineral density phenotypes in males with high or low BMD.European journal of human genetics : EJHG · 2011Article
- Genetic and hormonal control of bone volume, architecture, and remodeling in XXY mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Outcome of array CGH analysis for 255 subjects with intellectual disability and search for candidate genes using bioinformatics.Human genetics · 2010Article
- Molecular genetic studies of gene identification for osteoporosis: the 2009 update.Endocrine reviews · 2010Review
- Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Areal BMD (aBMD) and areal bone size (ABS) are biologically correlated traits and are each important determinants of bone strength and risk of fractures. Studies showed that aBMD and ABS are genetically correlated, indicating that they may share some common genetic factors, which, however, are largely unknown. To study the genetic factors influencing both aBMD and ABS, bivariate whole genome linkage analyses were conducted for aBMD-ABS at the femoral neck (FN), lumbar spine (LS), and ultradistal (UD)-forearm in a large sample of 451 white pedigrees made up of 4498 individuals. We detected significant linkage on chromosome Xq27 (LOD = 4.89) for LS aBMD-ABS. In addition, we detected suggestive linkages at 20q11 (LOD = 3.65) and Xp11 (LOD = 2.96) for FN aBMD-ABS; at 12p11 (LOD = 3.39) and 17q21 (LOD = 2.94) for LS aBMD-ABS; and at 5q23 (LOD = 3.54), 7p15 (LOD = 3.45), Xq27 (LOD = 2.93), and 12p11 (LOD = 2.92) for UD-forearm aBMD-ABS. Subsequent discrimination analyses indicated that quantitative trait loci (QTLs) at 12p11 and 17q21 may have pleiotropic effects on aBMD and ABS. This study identified several genomic regions that may contain QTLs important for both aBMD and ABS. Further endeavors are necessary to follow these regions to eventually pinpoint the genetic variants affecting bone strength and risk of fractures.
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Registered trials
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