ArticleThe Journal of rheumatology2008
Discrepancy between simultaneous digital skin microvascular and brachial artery macrovascular post-occlusive hyperemia in systemic sclerosis.
Article in The Journal of rheumatology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Atherosclerosis in systemic sclerosis: a systematic review and meta-analysis.Arthritis and rheumatism · 2011Pooled it
- Endothelial dysfunction in ME/CFS patients.PloS one · 2023Trial
- Brachial artery flow-mediated dilation in patients with systemic sclerosis: an experience from tertiary care center from North India.Clinical rheumatology · 2023Article
- Proprotein convertase subtilisin/kexin 9 (PCSK9) in patients with diffuse systemic sclerosis: A marker of disease activity and severe disease manifestations with potential therapeutic implementations.Archives of rheumatology · 2023Article
- Correlation between Microvascular Damage and Internal Organ Involvement in Scleroderma: Focus on Lung Damage and Endothelial Dysfunction.Diagnostics (Basel, Switzerland) · 2022Review
- Decreased Pulse Wave Velocity in a Systemic Sclerosis Population: Preliminary Results from a Cross-Sectional Study.Journal of personalized medicine · 2022Article
- Systemic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis.Microvascular research · 2021Article
- Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Results From Open-Label Cyclophosphamide Intervention Study.Frontiers in medicine · 2021Article
- Reproducibility and normalization of reactive hyperemia using laser speckle contrast imaging.PloS one · 2021Article
- Endothelial dysfunction in patients with systemic sclerosis.Postepy dermatologii i alergologii · 2020Article
- Impairment of microcirculation and vascular responsiveness in adolescents with primary Raynaud phenomenon.Pediatric rheumatology online journal · 2018Article
- A critical view on cardiovascular risk in systemic sclerosis.Rheumatology international · 2017Review
- Article
- Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction.Clinical rheumatology · 2015Article
- Cardiovascular disease in systemic sclerosis.Annals of translational medicine · 2015Review
- Ischemic arterial events and atherosclerosis in patients with systemic sclerosis: a population-based case-control study.Arthritis research & therapy · 2013Article
- [Critical limb ischemia in systemic sclerosis].Zeitschrift fur Rheumatologie · 2012Article
- Sildenafil increases digital skin blood flow during all phases of local cooling in primary Raynaud's phenomenon.Clinical pharmacology and therapeutics · 2012Article
- Cardiovascular disease in systemic sclerosis--an emerging association?Arthritis research & therapy · 2011Review
- Thermal provocation to evaluate microvascular reactivity in human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveVascular impairment, a main feature of the pathogenesis of systemic sclerosis (SSc), involves both the macro- and the microvasculature. We compared and correlated simultaneously measured skin microvascular and brachial artery macrovascular post-occlusive hyperemia in 3 groups: patients with SSc, patients with primary Raynaud's phenomenon (RP), and healthy volunteers.
methodsThirty-three healthy volunteers, 36 patients with primary RP, and 42 patients with SSc were enrolled. For each subject, brachial artery flow-mediated dilation (FMD) and cutaneous post-occlusive reactive hyperemia (PORH) were simultaneously recorded after 5-minute occlusion of the brachial artery. Local thermal hyperemia, nitroglycerin-mediated dilation (NMD), intima-media thickness (IMT), and pulse wave velocity (PWV) were also assessed.
resultsDigital cutaneous peak PORH was altered in patients with primary RP and SSc compared to healthy controls, whereas FMD was not significantly different among all groups. We observed a correlation between digital peak cutaneous vascular conductance and brachial FMD in healthy controls (r = 0.49; p = 0.004), but not in patients with primary RP or SSc. Thermal hyperemia was altered only in patients with SSc. Brachial NMD, IMT, and PWV were not different among all groups.
conclusionWe observed a loss of the correlation between brachial FMD and digital cutaneous PORH in patients with SSc and primary RP. Microvascular function is impaired in SSc, whereas brachial artery endothelial function is normal.
Indexed as
Identifiers
18597404PMC3291814W1909939624What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.