ArticleBreast cancer research and treatment2009
Matrix metalloproteinase-1 promotes breast cancer angiogenesis and osteolysis in a novel in vivo model.
Article in Breast cancer research and treatment, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- MMP1-induced NF-κB activation promotes epithelial-mesenchymal transition and sacituzumab govitecan resistance in hormone receptor-positive breast cancer.Cell death & disease · 2025Article
- Article
- Targeting Matrix Metalloproteinases and Their Inhibitors in Melanoma.International journal of molecular sciences · 2024Review
- Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization.Bone research · 2024Article
- Comparison between a novel salivary marker and several clinical prognosticators in oral cavity cancer.Laryngoscope investigative otolaryngology · 2023Article
- Weaving the nest: extracellular matrix roles in pre-metastatic niche formation.Frontiers in oncology · 2023Review
- The In Vivo Selection Method in Breast Cancer Metastasis.International journal of molecular sciences · 2021Review
- Breast Cancer Cells Metastasize to the Tissue-Engineered Premetastatic Niche by Using an Osteoid-Formed Polycaprolactone/Nanohydroxyapatite Scaffold.Computational and mathematical methods in medicine · 2021Article
- MiR-361-5p inhibits glycolytic metabolism, proliferation and invasion of breast cancer by targeting FGFR1 and MMP-1.Journal of experimental & clinical cancer research : CR · 2017Article
- What Is Breast in the Bone?International journal of molecular sciences · 2016Review
- A new prodrug form of Affibody molecules (pro-Affibody) is selectively activated by cancer-associated proteases.Cellular and molecular life sciences : CMLS · 2015Article
- Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13.Breast cancer research : BCR · 2014Article
- Plasma matrix metalloproteinase 1, 3, and 7 levels and breast cancer risk in the Nurses' Health study.Cancer causes & control : CCC · 2014Article
- Article
- RANKL/RANK/MMP-1 molecular triad contributes to the metastatic phenotype of breast and prostate cancer cells in vitro.PloS one · 2013Article
- The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model.BMC cancer · 2012Article
- Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation.Leukemia · 2012Article
- ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling.PloS one · 2012Article
- FH535 inhibited migration and growth of breast cancer cells.PloS one · 2012Article
- Homing of cancer cells to the bone.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Matrix metalloproteinase-1 (MMP-1) is critical for mediating breast cancer metastasis to bone. We investigated the role of MMP-1 in breast cancer invasion of soft tissues and bone using human MDA MB-231 breast cancer cells stably transfected with shRNAs against MMP-1 and a novel murine model of bone invasion. MMP-1 produced by breast cancer cells with control shRNA facilitated invasion of tumors into soft tissue in vivo, which correlated with enhanced blood vessel formation at the invasive edge, compared to tumors with silenced MMP-1 expression. Tumors expressing MMP-1 were also associated with osteolysis in vivo, whereas tumors with inhibited MMP-1 levels were not. Additionally, tumor-secreted MMP-1 activated bone-resorbing osteoclasts in vitro. Together, these data suggest a mechanism for MMP-1 in the activation of osteoclasts in vivo. We conclude that breast cancer-derived MMP-1 mediates invasion through soft tissues and bone via mechanisms involving matrix degradation, angiogenesis, and osteoclast activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.