ArticleJournal of thrombosis and thrombolysis2009
Effects of sleep and sleep deprivation on blood cell count and hemostasis parameters in healthy humans.
Article in Journal of thrombosis and thrombolysis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- The Effect of Low-Dose Acetylsalicylic Acid on Cellular Immune Responses to Experimental Sleep Restriction in Healthy Humans.Neuroimmunomodulation · 2026Trial
- A crosstalk between the immune system and obstructive sleep apnea.Frontiers in immunology · 2026Review
- Prestroke sleep and stroke: a narrative review.Sleep & breathing = Schlaf & Atmung · 2025Review
- Suppressed DNA repair capacity in flight attendants after air travel.Scientific reports · 2025Article
- Sleep Duration Polygenic Risk and Phenotype: Associations with Biomarkers of Accelerated Aging in the Baltimore Longitudinal Study of Aging.International journal of aging & human development · 2025Article
- Exploring the Dynamics of Sleep Deprivation: Insights into Complete Blood Count and Coagulation Parameters in a Case-Control Study.Advances in hematology · 2024Article
- Article
- Patient-reported sleep outcomes lack association with mucosal eosinophilia or neutrophilia in patients with chronic rhinosinusitis undergoing functional endoscopic sinus surgery.International forum of allergy & rhinology · 2021Article
- Automated feature extraction from population wearable device data identified novel loci associated with sleep and circadian rhythms.PLoS genetics · 2020Article
- Association between lifestyle and hematological parameters: A study of Chinese male steelworkers.Journal of clinical laboratory analysis · 2019Article
- The Sleep-Immune Crosstalk in Health and Disease.Physiological reviews · 2019Review
- Article
- Sleep Duration and Cardiovascular Disease Risk: Epidemiologic and Experimental Evidence.Sleep medicine clinics · 2016Review
- Objective assessment of health or pre-chronic disease state based on a health test index derived from routinely measured clinical laboratory parameters.Journal of translational medicine · 2015Article
- Quantitatively plotting the human face for multivariate data visualisation illustrated by health assessments using laboratory parameters.Computational and mathematical methods in medicine · 2013Article
- Sleep-immune system interaction: advantages and challenges of human sleep loss model.Frontiers in neurology · 2012Article
- Chronic sleep deprivation markedly reduces coagulation factor VII expression.Haematologica · 2010Article
- The impact of shift work induced chronic circadian disruption on IL-6 and TNF-alpha immune responses.Journal of occupational medicine and toxicology (London, England) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of the study was to investigate the effects of 24 h of sleep deprivation on hematologic parameters.
methodsTen healthy subjects (5 Men, 5 Women, 19-23 years old) were studied from 07:00 on day 1 until 07:00 on day 3 and allowed to have normal sleep during night 1 (providing control data) followed by staying awake from 07:00 h on day 2 until 07:00 h on day 3 (providing sleep deprivation data). Blood samples were drawn from the antecubital vein on each day at 07.00 h. Blood cell counts were measured with an automated hematology analyzer. Hemostasis parameters included activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), and fibrinogen level (FIB), which were analyzed with an autoanalyser. ANOVA test with repeated measures was performed.
resultsThe white blood cell and neutrophil granulocyte counts were significantly higher (P < 0.01) and PT, APTT, and TT significantly shorter (P < 0.05) on day 3 (following sleep deprivation) than on days 1 or 2.
conclusionSleep deprivation may worsen systemic inflammation and hypercoagulable states, which are known to be involved in the pathogenesis of diseases such as cerebrovascular or cardiovascular disease.
Indexed as
Identifiers
18597046What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.