ArticlePLoS neglected tropical diseases2008
On the extent and origins of genic novelty in the phylum Nematoda.
Article in PLoS neglected tropical diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 79 citations in OpenAlex.
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- Expanding the view on the evolution of the nematode dauer signalling pathways: refinement through gene gain and pathway co-option.BMC genomics · 2016Article
- s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways.Cell metabolism · 2015Article
- Caenorhabditis elegans is a useful model for anthelmintic discovery.Nature communications · 2015Article
- Co-evolution between an endosymbiont and its nematode host: Wolbachia asymmetric posterior localization and AP polarity establishment.PLoS neglected tropical diseases · 2014Article
- The transcriptome of the invasive eel swimbladder nematode parasite Anguillicola crassus.BMC genomics · 2013Article
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- A molecular analysis of desiccation tolerance mechanisms in the anhydrobiotic nematode Panagrolaimus superbus using expressed sequenced tags.BMC research notes · 2012Article
- Toward 959 nematode genomes.Worm · 2012Review
- A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation.PLoS neglected tropical diseases · 2012Article
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- What Nematode genomes tell us about the importance of horizontal gene transfers in the evolutionary history of animals.Mobile genetic elements · 2011Article
- Genomic insights into the origin of parasitism in the emerging plant pathogen Bursaphelenchus xylophilus.PLoS pathogens · 2011Article
- RNAi effector diversity in nematodes.PLoS neglected tropical diseases · 2011Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThe phylum Nematoda is biologically diverse, including parasites of plants and animals as well as free-living taxa. Underpinning this diversity will be commensurate diversity in expressed genes, including gene sets associated specifically with evolution of parasitism. METHODS AND
findingsHere we have analyzed the extensive expressed sequence tag data (available for 37 nematode species, most of which are parasites) and define over 120,000 distinct putative genes from which we have derived robust protein translations. Combined with the complete proteomes of Caenorhabditis elegans and Caenorhabditis briggsae, these proteins have been grouped into 65,000 protein families that in turn contain 40,000 distinct protein domains. We have mapped the occurrence of domains and families across the Nematoda and compared the nematode data to that available for other phyla. Gene loss is common, and in particular we identify nearly 5,000 genes that may have been lost from the lineage leading to the model nematode C. elegans. We find a preponderance of novelty, including 56,000 nematode-restricted protein families and 26,000 nematode-restricted domains. Mapping of the latest time-of-origin of these new families and domains across the nematode phylogeny revealed ongoing evolution of novelty. A number of genes from parasitic species had signatures of horizontal transfer from their host organisms, and parasitic species had a greater proportion of novel, secreted proteins than did free-living ones.
conclusionsThese classes of genes may underpin parasitic phenotypes, and thus may be targets for development of effective control measures.
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