ArticlePloS one2008
Maternal feeding controls fetal biological clock.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life.Journal of immunology research · 2024Trial
- 11β-HSD2 buffers fetal glucocorticoid exposure inducingPNAS nexus · 2026Article
- Endocrinology in maternal-fetal synchronization and developmental origins of susceptibility to metabolic diseases.Endocrine journal · 2026Review
- Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care.Clinics in perinatology · 2025Review
- Peripheral clock gene oscillations are perturbed in neonatal and adult rat offspring raised under adverse limited bedding conditions.Scientific reports · 2023Article
- Review
- Article
- Development of the circadian system in early life: maternal and environmental factors.Journal of physiological anthropology · 2022Review
- Maternal-Fetal Circadian Communication During Pregnancy.Frontiers in endocrinology · 2020Review
- Fetal Programming of Renal Dysfunction and High Blood Pressure by Chronodisruption.Frontiers in endocrinology · 2019Article
- Maternal eating behavior is a major synchronizer of fetal and postnatal peripheral clocks in mice.Cellular and molecular life sciences : CMLS · 2018Article
- Perinatal Programming of Circadian Clock-Stress Crosstalk.Neural plasticity · 2018Review
- Use of radiotelemetry to assess perinatal cardiac function in the ovine fetus and newborn.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Article
- l-Ornithine affects peripheral clock gene expression in mice.Scientific reports · 2016Article
- Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.British journal of pharmacology · 2014Article
- The development of sleep-wake rhythms and the search for elemental circuits in the infant brain.Behavioral neuroscience · 2014Review
- Embryonic development of circadian clocks in the mammalian suprachiasmatic nuclei.Frontiers in neuroanatomy · 2014Review
- Article
- Designing artificial environments for preterm infants based on circadian studies on pregnant uterus.Frontiers in endocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is widely accepted that circadian physiological rhythms of the fetus are affected by oscillators in the maternal brain that are coupled to the environmental light-dark (LD) cycle. METHODOLOGY/PRINCIPAL
findingsTo study the link between fetal and maternal biological clocks, we investigated the effects of cycles of maternal food availability on the rhythms of Per1 gene expression in the fetal suprachiasmatic nucleus (SCN) and liver using a transgenic rat model whose tissues express luciferase in vitro. Although the maternal SCN remained phase-locked to the LD cycle, maternal restricted feeding phase-advanced the fetal SCN and liver by 5 and 7 hours respectively within the 22-day pregnancy. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that maternal feeding entrains the fetal SCN and liver independently of both the maternal SCN and the LD cycle. This indicates that maternal-feeding signals can be more influential for the fetal SCN and particular organ oscillators than hormonal signals controlled by the maternal SCN, suggesting the importance of a regular maternal feeding schedule for appropriate fetal molecular clockwork during pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.